Tag: septic shock

1. In this randomized clinical trial, intravenous infusion of high-dose vitamin C vs placebo for 96 hours resulted in no significant differences in the modified Sequential Organ Failure Assessment score at 96 hours or in levels of C-reactive protein and thrombomodulin at 168 hours. 2. There were three secondary outcomes...
1. In this randomized clinical trial, intravenous infusion of high-dose vitamin C vs placebo for 96 hours resulted in no significant differences in the modified Sequential Organ Failure Assessment score at 96 hours or in levels of C-reactive protein and thrombomodulin at 168 hours. 2. There were three secondary outcomes...
1. Patients with septic shock in the intensive care unit (ICU) undergoing mechanical ventilation and managed with adjunctive continuous hydrocortisone infusion, did not have a lower 90-day mortality compared to placebo. 2. There was no difference between the placebo and hydrocortisone groups in secondary outcomes of mortality at 28 days,...
1. No moderate- or high-level evidence was found that SEP-1 or its hemodynamic interventions increase survival in septic adults. 2. The authors suggest that the CMS should evaluate its approval process to ascertain how interventions that are deficient in evidence were adopted and how improvements can be made to this...
Complete Dissection or Observation for Sentinel-Node Metastasis in Melanoma The pathological status of the sentinel node, gathered via biopsy, is the most important prognostic factor in melanoma. This study aims to examine melanoma-specific 3-year survival, as it relates to complete lymph-node dissection versus observation in patients who are positive for...
1. Sepsis, now defined as “life threatening organ dysfunction caused by a dysregulated host response to infection,” can be identified by a change of 2 or more points in a patient’s Sequential Organ Failure Assessment (SOFA) score. 2. Among patients with a suspected infection, the quick SOFA (qSOFA) score can...
1. Septic shock is a complication of infection with very high mortality rates. 2. This study was one of the first to demonstrate that delaying the provision of effective antimicrobial therapy in septic shock leads to significantly higher mortality rates. 3. It supported recommendations by international guidelines to initiate broad-spectrum, empiric...
1. Early, goal-directed therapy was shown to reduce mortality in severe sepsis and septic shock in a single-center, randomized controlled trial. 2. This multicenter trial conducted in England demonstrated that early, goal-directed therapy did not significantly reduce 90-day mortality in patients with severe sepsis and septic shock when compared to...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Goal-Directed Resuscitation for Patients with Early Septic Shock The monumental Rivers et al publication laid forth the groundwork for early goal-directed therapy (EGDT) for sepsis management, a framework that has been embraced...
Image: PD  In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa Tuberculosis (TB) is difficult to diagnose microbiologically in children, as the majority of childhood cases produce negative smears and cultures...