• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Emergency

Intravenous fluid restriction does not improve septic shock outcomes

byBryant LimandKiera Liblik
June 27, 2022
in Emergency, Infectious Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. There was no significant difference in mortality among septic shock patients in the intensive care unit (ICU) between standard and restricted intravenous (IV) fluid treatment.

2. There were no significant differences in the incidence of serious adverse events between standard and restricted intravenous fluid treatment.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Early and aggressive fluid resuscitation is known to improve survival in patients with septic shock. Yet, excessive fluid administration following initial resuscitation could lead to edema and organ damage. Currently, there are no guidelines for using restrictive or standard IV fluid strategies in patients with septic shock after initial resuscitation due to a paucity of data on their comparative outcomes. The present randomized trial evaluated adult patient mortality and adverse events of restriction and standard IV fluid strategies for septic shock patients in the ICU. Patients were followed for 90 days after starting treatment. There were no significant differences in mortality at 90 days between standard and restricted strategies. The incidence of serious adverse events was also not significantly different between groups. However, patient recruitment was limited to study sites in European countries, which can reduce generalizability to other populations. Violations in IV fluid protocol (21.5% and 13% in restrictive- and standard-fluid groups respectively) could also affect patient and study outcomes.

Click to read the study in NEJM

In-Depth [randomized controlled trial]: In the present study, ICU patients over the age of 18 with septic shock onset within 12 hours of screening (n=1,554) were randomly assigned to receive the standard or restrictive IV fluid therapy in a 1:1 ratio. For the restrictive-fluid group, IV fluid could only be given to correct severe hypoperfusion, replace documented fluid loss such as gastrointestinal or drain losses, maintain a daily fluid intake of one liter, or for patients with contraindication for oral fluid intake. Patients were followed for 90 days after enrolling in the study. Patients remained in the ICU for a median of 5 days (interquartile ranges, 3 to 9 days for restrictive-fluid patients and 3 to 10 days for standard-fluid patients). The restrictive- and standard-fluid groups received a median of 1798mL and 3811mL of IV fluids, respectively. There was no significant difference in mortality between the restrictive- (42.3%) and standard-fluid (42.1%) groups. Similarly, no differences between the two groups were found in survival durations without life support or after hospital discharge. There was also no significant difference in the incidence of serious adverse events in the restrictive- (29.4%) and standard-fluid (30.8%) groups. Severe adverse events included cerebral, cardiac, intestinal, or limb ischemic events. In summary, the results from this study may support new guidelines for fluid management for ICU patients with septic shock.

RELATED REPORTS

Frailty scores alone may be poor predictors of intensive care admission or hospital stay duration

Trimethoprim-sulfamethoxazole during pregnancy does not reduce risk of prematurity

Intravenous hydrocortisone may reduce risk of kidney failure in patients with sepsis

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

 

Tags: emergencyfluid restrictionICUinfectious diseaseintensive care unitintravenous fluidssepsisseptic shock
Previous Post

Intravenous vitamin C increases mortality and organ dysfunction in sepsis patients

Next Post

#VisualAbstract: Varenicline improves successful smoking cessation amongst African American daily smokers: KIS-IV Trial

RelatedReports

Chronic Disease

Frailty scores alone may be poor predictors of intensive care admission or hospital stay duration

June 16, 2025
Implementation of pneumococcal vaccine programs linked to decreased antibiotic prescription
Infectious Disease

Trimethoprim-sulfamethoxazole during pregnancy does not reduce risk of prematurity

June 9, 2025
Being overweight and obese associated with increased incidence of chronic kidney disease
Emergency

Intravenous hydrocortisone may reduce risk of kidney failure in patients with sepsis

June 5, 2025
Government-funded initiatives provide important supports to low-income HIV patients
Infectious Disease

Second-line TAF-based ART improves viral suppression in pediatric HIV

June 4, 2025
Next Post
#VisualAbstract: Varenicline improves successful smoking cessation amongst African American daily smokers: KIS-IV Trial

#VisualAbstract: Varenicline improves successful smoking cessation amongst African American daily smokers: KIS-IV Trial

Improved glycemic control in type 1 diabetics on very low-carbohydrate diets

Improved diet quality may be associated with increased longevity and better aging in Israeli adults

Smoking during pregnancy associated with aerobic fitness of children

Heavy smoking is associated with visual field loss in glaucoma

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Weighted vests and resistance training confer similar outcomes for bone density in the elderly
  • Breast cancer survivors may have a lower risk of Alzheimer’s dementia
  • Evaluating scar outcomes in pediatric burn patients following skin grafting 
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.