Tag: statin

1. In this prespecified secondary analysis of a randomized controlled trial, patients with acute coronary syndrome (ACS) who received a loading dose of atorvastatin prior to percutaneous coronary intervention (PCI) and again 24 hours post-PCI had lower rates of major adverse cardiovascular events at 30 days compared with patients...
1. In this case control study from Australia, patients with histologically confirmed idiopathic inflammatory myositis (IIM) were more likely to report exposure to statin medications than population-matched controls. 2. The connection between statin use and IIM remained after excluding necrotizing myositis. Evidence Rating Level: 3 (Average) Study Rundown: Statins are among the...
1. High levels of agreement between statin eligibility found between several guidelines included in this study. 2. Statin eligibility, among patients, increased significantly with increased age. Evidence Rating Level: 2 (Good) Study Rundown: Statins remain an important therapy to help reduce the number of atherosclerotic cardiovascular disease (ASCVD) events. Statins have been...
1. In patients with stable coronary heart disease (CHD), high-dose atorvastatin significantly reduced the risk of major cardiovascular events when compared to low-dose. 2. Patients in the high-dose group experienced significantly higher rates of adverse events, though the rate of statin-related myalgias were similar in the two groups.  Original Date of...
1. In this post-hoc analysis of the Lipid-Lowering Trial (LLT) component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT-LLT) randomized control trial, pravastatin use for patients over 65 years with no evidence of atherosclerotic vascular disease did not reduce all cause or cardiovascular mortality. 2. There...
  Dry Care Versus Antiseptics for Umbilical Cord Care: A Cluster Randomized Trial Because omphalitis is rare in developed countries, the benefit of antiseptic use in umbilical cord care have not been shown. The purpose of this study was to assess the noninferiority of dry care compared with antiseptics in France...
Cardiovascular Safety of Celecoxib, Naproxen, or Ibuprofen for Arthritis  Celecoxib is a selective COX-2 inhibitor used for analgesia as an alternative to nonselective nonsteroidal anti-inflammatory drugs (NSAIDs), however the cardiovascular risk profile is controversial. In this multicenter, industry sponsored, randomized control trial, 24,081 patients with osteoarthritis or rheumatoid arthritis were...
1. Statin therapy significantly reduced the risk of cardiovascular disease (CVD) in patients with intermediate cardiovascular risk for disease. Specifically, statin therapy was associated with a significant decrease in a composite cardiovascular endpoint consisting of cardiovascular-related death, nonfatal stroke, and nonfatal myocardial infarction (MI). 2. There was no significant difference seen...
Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes HMG-CoA reductase inhibitors (statins) lower LDL cholesterol levels and reduce the risk of cardiovascular events. Ezetimibe is a non-statin lipid lowering medication that reduces the absorption of cholesterol in the intestines and can further decrease LDL cholesterol levels when added...
1. Amongst a population of patients enrolled in palliative care secondary to advanced life-limiting illness, discontinuing their statin therapy did not lead to an increased proportion of deaths within the first two months, or time to first cardiovascular-related event. 2. While there was a trend towards improved quality of life...