Tag: statin

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Adjuvant Paclitaxel and Trastuzumab for Node-Negative, HER2-Positive Breast Cancer Trastuzumab has been shown to be an effective therapy for Stage II and III HER2-positive breast cancers in multiple large trials. However, whether...
1. Based on the results of the trial, there was no difference in the rates of osteoporotic fractures between the group receiving statin therapy compared to the group receiving placebo. 2. Additionally, rising levels of high-sensitivity C-reactive protein (hs-CRP), which is an inflammatory marker related to cardiovascular disease, was not...
Image: PD  1. High dose simvastatin therapy reduced the annual brain atrophy rate over two years compared to placebo in patients with secondary progressive multiple sclerosis (MS).  2. Simvastatin was associated with a small but significant reduction in MS disability scores compared to placebo.  Evidence Rating Level: 1 (Excellent)  Study Rundown: Multiple sclerosis...
Image: PD 1. New clinical guidelines from the American College of Cardiology (ACC) and the American Heart Association (AHA) recommend statin use in certain patient populations based on age, 10-year atherosclerotic cardiovascular disease (ASCVD) risk level, and blood LDL-C level. 2. The guidelines also suggest use of a new equation for...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Thrombus Aspiration during ST-Segment Elevation Myocardial Infarction Thrombus aspiration is used as an adjunct for managing ST-segment elevation myocardial infarctions (STEMI) and occurs prior to percutaneous coronary intervention (PCI).  Previous...
Image: PD 1. Statin use was associated with a higher risk of cataract formation (OR 1.09; p=0.01). Length of statin use was associated with cataract formation, not dosage (OR 1.001; p<0.001). 2. Statin use is an independent predictor of cataract formation (OR 1.43; R2 = 0.52). Evidence Rating Level: 2 (Good)  Study Rundown:...