Tag: stem cells

1. Patients with chronic graft-vs-host disease (CGVHD) after allogeneic hematopoietic stem cell transplantation (AHSCT) were more likely to develop cutaneous autoimmune diseases when there was female donor to male recipient sex mismatch or if the patient had Anticardiolipin (ACA) IgG antibodies.                                            2. In patients with CGVHD, there was no...
1. In this case study, two patients with chronic HIV infection who underwent hematopoietic stem cell transplant achieved HIV remission for several weeks after their antiretroviral therapy was stopped. 2. However, both patients subsequently experienced viral rebound associated with the acute retroviral syndrome. Evidence Rating Level: 4 (Below average)  Study Rundown: Latent...
1. 83% of sickle cell patients receiving a nonmyeloablative, hematopoetic stem cell transplant demonstrated full donor-type hemoglobin one-year post transplantation.  2. No patient has developed graft-versus-host disease thus far.  Evidence Rating Level: 2 (Good)             Study Rundown: Sickle cell disease is caused by a mutation in the beta-globin...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Atrial Fibrillation in Patients with Cryptogenic Stroke Patients experiencing a stroke or transient ischemic attack (TIA) often undergo diagnostic workup involving 24 hour ECG monitoring for atrial fibrillation.  However, it is suspected...
Image: PD/CDC  1. In recipients of allogeneic hematopoetic-cell transplants, letermovir was effective in reducing the incidence CMV infections in a dose dependent manner.  2.  Treatment with letermovir was as safe as placebo, with no indication of hematologic toxicity or nephrotoxicity.  Evidence Rating Level: 1 (Excellent)  Study Rundown: Cytomegalovirus (CMV) disease, due to reactivation...
Image: CC/Wiki 1. Breast augmentation by water-assisted lipotransfer (WAL) without stem cell enrichment was faster and more cost effective. 2. WAL alone resulted in at least an equal take rate when compared to WAL with stem cell enrichment.  Evidence Rating Level: 3 (Average)  Study Rundown: Water-assisted lipotransfer reduces the amount adipose-tissue derived stem...
Image: PD 1. Autologous stem-cell transplantation improved progression-free survival in patients with high-intermediate-risk and high-risk disease, but did not show improvement in overall survival. 2. Retrospective subgroup analysis suggests that early transplantation may provide greater benefit to patients with high-risk disease than patients with high-intermediate-risk disease. Evidence Rating Level: 2 (Good) Study Rundown:...
Image: PD/CMV 1. Administering CMX001 at 100 mg twice weekly for post-hematopoietic cell transplant patients provides effective prophylaxis against cytomegalovirus (CMV) infection.  2. The incidence of adverse events, particular acute graft-versus-host disease and diarrhea, appear to be dose-dependent in patients receiving CMX001.  Evidence Rating Level: 2 (Good)            Study...
Image: PD RANKL protein structure 1. Continued monoclonal protein response to autologous stem cell transplantation (ASCT) is associated with improved progression-free survival, time to next therapy and overall survival. 2. This marker should be considered in post-transplant care of multiple myeloma (MM) patients. Evidence rating: 2 (Good) Study Rundown: The treatment options for multiple...