Tag: stem cells

1. In this study of 3-dimensional cerebral organoids of schizophrenia patients and healthy controls, differences were found in mitochrondrial function, response to stimulation and depolarization, ATP production, and overall pathway and neuronal generation deficits. Evidence Rating Level: 3 (Average) Patient-derived induced pluripotent stem cells (iPSCs) come from somatic cells through cellular reprogramming...
1. Allo-HSCT treatment resulted in significant prolonged reduction in HIV-1 viral reservoirs. 2. Mouse models showed adoptive transfer of peripheral CD4+ T cells to immunosuppressed mice resulted in no rebound of the viral load. Evidence Rating Level: 2 (Good) Study Rundown: While combination antiretroviral therapy (cART) has been highly successful at reducing...
1. After undergoing a transient myocardial infarction (MI), primates injected with stem cells showed improved heart function. 2. None of the primates that received the stem cells developed a tumor from these cells or experienced immune rejection, demonstrating the treatment’s potential safety. Evidence Rating Level: 1 (Excellent) Study Rundown: Heart attacks,...
1. Hematopoietic stem cells (HSCs) were engineered to moderately overexpress platelet-derived growth factor (PDGF-BB), an important bone growth factor. 2. Mice transplanted with HSCs moderately overexpressing PDGF-BB showed increased levels of the bone formation marker alkaline phosphatase (ALP), bone formation, and bone strength compared to untreated mice or mice...
1. Harvesting mouse hematopoietic stem cells (HSCs) in hypoxia (3% oxygen) rather than ambient air (21% oxygen) resulted in greatly increased stem cell numbers, both at the time of collection and after transplantation into recipient mice. 2. Using the drug cyclosporin A (CSA) during ambient air harvest of mouse...
1. Adipose derived stem cells (ADSCs), transfected to overexpress hepatic growth factor (HGF) or to silence HGF expression, were injected into irradiated rats to examine their ability to protect against radiation-induced liver damage. 2. The HGF-overexpressing ADSCs appeared to mitigate liver damage, increasing liver cell proliferation and reducing liver cell...
1. When stimulated with a variety of growth and inflammatory factors, embryonic stem cells (ESCs) took on a macrophage-like phenotype, which is associated with immune-suppression. 2. The stimulated ESCs (ES-SCs) appeared to prolong non-self graft survival in mice by suppressing immune cell activity at the graft site. Evidence Rating Level:...
1. In children with hematologic malignancy, there was no significant difference in terms of 1-year survival between single- and double-unit cord-blood transplantation groups. 2. Children who received double-unit cord-blood transplantation were more likely to experience delayed platelet recovery and graft-versus-host disease. Evidence Rating Level: 1 (Excellent)       Study Rundown: Unrelated-donor...
1. Treatment with human-embryonic stem cell-derived (hESC-derived) retinal pigment epithelium led to improved visual acuity and vision-related quality-of-life measures for patients with age-related macular degeneration and Stargardt’s macular dystrophy. 2. No evidence of serious ocular or systemic safety issues, adverse proliferation, or rejection related to the hESC-derived tissue was...
1. Patients with chronic graft-vs-host disease (CGVHD) after allogeneic hematopoietic stem cell transplantation (AHSCT) were more likely to develop cutaneous autoimmune diseases when there was female donor to male recipient sex mismatch or if the patient had Anticardiolipin (ACA) IgG antibodies.                                            2. In patients with CGVHD, there was no...