Tag: transplant
Check out the original article from the Lancet Haematology here.
1. Oxygenated hypothermic machine perfusion (HMPO2) of kidneys donated after circulatory death was associated with fewer severe complications and lower rates of graft failure compared to hypothermic machine perfusion without oxygenation (HMP).
2. There was no significant difference in mean eGFR between HMPO2 and HMP despite potential beneficial effects suggested...
1. Oxygenated hypothermic machine perfusion (HMPO2) of kidneys donated after circulatory death was associated with fewer severe complications and lower rates of graft failure compared to hypothermic machine perfusion without oxygenation (HMP).
2. There was no significant difference in mean eGFR between HMPO2 and HMP despite potential beneficial effects suggested...
1. Following treatment with glucocorticoids, human hematopoietic stem cells (HSCs) from cord blood demonstrated enhanced homing and engraftment to bone marrow in mice.
2. Glucocorticoids improved HSC homing by increasing histone acetylation, which resulted in increased CXCR4 expression.
Evidence Rating Level: 2 (Good)
Study Rundown: HSCs from cord blood are used for...
1. A targeted immunoproteasome inhibitor, DPLG3, was found to have high selectivity for the immune cell proteasome and was not toxic to other cell types.
2. When administered after a heart transplant in mice, DPLG3 allowed for minimal graft rejection through a decrease in T cell activation.
Evidence Rating Level: 1...
1. Survival after allogeneic hematopoietic cell transplant was better in patients treated with cord blood than in patients treated with either HLA-matched or HLA-mismatched bone marrow or peripheral blood transplant.
2. Patients treated with cord-blood showed a lower risk of acute leukemia or myelodysplastic syndrome relapse than patients treated with...
1. When stimulated with a variety of growth and inflammatory factors, embryonic stem cells (ESCs) took on a macrophage-like phenotype, which is associated with immune-suppression.
2. The stimulated ESCs (ES-SCs) appeared to prolong non-self graft survival in mice by suppressing immune cell activity at the graft site.
Evidence Rating Level:...
1. In children with hematologic malignancy, there was no significant difference in terms of 1-year survival between single- and double-unit cord-blood transplantation groups.
2. Children who received double-unit cord-blood transplantation were more likely to experience delayed platelet recovery and graft-versus-host disease.
Evidence Rating Level: 1 (Excellent)
Study Rundown: Unrelated-donor...
1. Depletion of all Foxp3+ regulatory T-cells (Tregs) induced rejection of stable skin and heart allogeneic transplants in a hematopoietic chimeric mouse model.
2. The presence of either donor or recipient Tregs was sufficient to maintain tolerance of both skin and heart transplants.
Evidence Rating Level: 2 (Good)
Study Rundown: Allogeneic transplants,...