Tag: warfarin

1. In this observational study, patients who received one of three direct oral anticoagulants (DOACs) were significantly less likely to have an osteoporotic hip or vertebral fracture compared to those who received warfarin. 2. No difference in fracture risk was detected between individual DOACs. Evidence Rating Level: 2 (Good) Study Rundown: Osteoporotic...

1. In this randomized study comparing the efficacy of rivaroxaban with warfarin, dose-adjusted rivaroxaban treatment resulted in near doubling of risk for recurrent thrombosis. 2. The two treatment groups experienced similar bleeding outcomes, but patients in the rivaroxaban group had a higher stroke incidence rate. Evidence Rating Level: 1 (Excellent) Study Rundown:...

Central venous thrombosis (CVT) is a form of stroke characterized by thrombosis of cerebral veins or dural sinuses. While less than 5% of the 1.3 to 1.6 per 100,000 who experience CVT die by this cause, those who survive are at an increased risk of venous thrombotic events, and...

1. In this retrospective cohort study conducted in Michigan, aspirin therapy combined with warfarin for patients without a clinical indication was associated with increased rates of major bleeding, emergency visits for bleeding, and hospital admissions for bleeding. 2. Among these patients, there was no difference in rates of thrombosis or...

Association between antithrombotic medication use after bioprosthetic aortic valve replacement and outcomes in the Veterans Health Administration system Patients that have undergone bioprosthetic aortic valve replacement (bAVR) are at an increased risk of thromboembolism. Recommendations and strategies surrounding the use of antithrombotic medications, however, vary. In this retrospective cohort study,...

1. Aspirin combined with warfarin was linked with increased bleeding but not less thromboembolism compared with aspirin alone after bioprosthetic aortic valve replacement. 2. Dual antiplatelet therapy showed a non-significant trend towards increased bleeding but no less thromboembolism compared with aspirin alone after bioprosthetic aortic valve replacement. Evidence Rating Level: 2...

Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct Endovascular thrombectomy has been shown to have clinical benefit in patients with acute stroke when performed within 6 hours after the onset of stroke symptoms. However, it is unclear whether there is any clinical benefit if...

1. The incidence of major bleeding events up to 8 weeks after catheter-directed atrial fibrillation ablation was significantly lower in those receiving continuous therapy with dabigatran compared to those receiving INR-directed warfarin. 2. Both groups experienced similar incidence of minor bleeding events and thromboembolic events. Evidence Rating Level: 1 (Excellent) Study Rundown:...

1. In patients with atrial fibrillation (AF) who undergo percutaneous coronary intervention (PCI), treatment with rivaroxaban, in addition to dual antiplatelet therapy (DAPT), led to significantly lower rates of clinically significant bleeding compared to treatment with DAPT and dose-adjusted vitamin K antagonist. 2. There were no significant differences between the...

Tinazaparin vs Warfarin for Treatment of Acute Venous Thromboembolism in Patients with Active Cancer: A Randomized Clinical Trial Cancer-associated venous thromboembolism (VTE) represents a major source of morbidity and mortality among patients receiving systemic chemotherapy. Based largely on the results of a single, large randomized trial and several smaller studies,...