• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Total mucin concentration is associated with chronic bronchitis phenotype

byJames RoebkerandDayton McMillan
September 8, 2017
in Chronic Disease, Public Health, Pulmonology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. Total airway mucin concentration was significantly elevated in current or former smokers with chronic bronchitis compared to non-smoker controls, and correlated with disease severity.

2. Concentrations of mucin subtypes MUC5AC and MUC5B were elevated relative to non-smoker controls, with a significantly higher MUC5AC-to-MUC5B ratio in smokers with mild-to-moderate COPD.

Evidence Rating Level: 2 (Good)       

Study Rundown: Chronic bronchitis is a disease process hypothesized to occur secondary to mucus accumulation and poor mucus clearance in the airways. Mucin produced in the airways may be correlated with severity of chronic bronchitis, and a correlation is found may be a target for therapeutic research.   The Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS) is a large, multicenter study designed to further the understanding of COPD, determine biomarkers for future therapy and clinical trials, and divide COPD into homogeneous subgroups. In this study, the authors examined the utility of measuring total mucin concentration and the concentrations of MUC5B and MUC5AC mucin constituents as specific biomarkers for the chronic bronchitis phenotype. The results demonstrated a significant association between total mucin concentration and a questionnaire-diagnosis of chronic bronchitis. Receiver-operating-characteristic (ROC) curve analyses reported good sensitivity and specificity for total mucin concentration as a biomarker for chronic bronchitis. Additionally, the chronic bronchitis phenotype was associated with a specific ratio of the MUC5B and MUC5AC mucin constituents. These findings support total mucin concentration as a possible biomarker for the diagnosis and management of chronic bronchitis.

This was a multicenter, observational, cross-sectional study that aids prospective studies of biomarker, phenotypic, and clinical data in COPD. The data helps guide future therapy potentially aimed at reducing mucin production, provides clinical endpoints for future trials, and informs the pathogenesis of chronic bronchitis. The main limitation was the observational study design.

Click to read the study, published in NEJM

RELATED REPORTS

Mepolizumab decreases exacerbations in patients with eosinophilic COPD

Poor baseline lung function associated with increased risk of incident tuberculosis

Motivational interviewing not effective in reducing rehospitalisation and improving patient activation among patients with respiratory failure

Relevant Reading: Characteristics and prevalence of asthma/chronic obstructive pulmonary disease overlap in the United States

In-Depth [cross-sectional study]: SPIROMICS enrolled 2981 individuals with COPD in four groups: non-smoker controls, smokers without airflow obstruction, smokers with mild-moderate airflow obstruction, and smokers with severe airway obstruction. Current and former smokers had a greater than 20 pack-year history. Chronic bronchitis was diagnosed by questionnaire, either via the classical definition or the St. George’s Respiratory Questionnaire [SGRQ]). Emphysema was diagnosed based on computed tomography findings. Total mucin concentration was measured with chromatography after hypertonic saline sputum induction in 917 patients. The concentrations of MUC5B and MUC5AC were measured with mass spectroscopy in a subgroup of 148 patients. Total mucin concentration and questionnaire data were also analyzed in an independent cohort of 94 patients.

The mean total mucin concentration was significantly higher in all current or former smokers with reported phlegm production than non-smokers (3166±402 vs. 1515±152 mcg/mL). Sensitivity analyses also correlated total mucin concentration with COPD severity. All findings remained significant after adjustment for smoking status, asthma status, and frequency of respiratory exacerbations. Total mucin concentrations were higher in patients who experienced exacerbations (2 or more exacerbations/year, 4194±878 mcg/mL; 0-2 exacerbations/year, 2848±171 mcg/mL; 0 exacerbations, 2458±113 mcg/mL). Both MUC5B and MUC5AC were elevated in smokers versus non-smokers (296±65 vs 108±20 for MUC5B; 108±31 vs 10±4 for MUC5AC), and MUC5AC concentrations were disproportionately elevated in smokers with mild-to-moderate COPD (ratio of MUC5AC to MUC5B of 0.5±0.1 vs. 0.1±0.04 in non-smokers). Finally, the area under the ROC curve (AUC) for total mucin concentration versus a diagnosis of chronic bronchitis was 0.72 (95% confidence interval [CI], 0.65 to 0.79) in the SPIROMICS cohort and 0.82 (95% CI, 0.73 to 0.92) in the independent cohort.

Image: PD

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc

Tags: Bronchitiscopd
Previous Post

Tiotropium linked with improved outcomes in early-stage COPD

Next Post

Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease

RelatedReports

2 Minute Medicine Rewind May 20, 2019
Chronic Disease

Mepolizumab decreases exacerbations in patients with eosinophilic COPD

May 20, 2025
Lessons from real-world implementation of lung cancer screening
Chronic Disease

Poor baseline lung function associated with increased risk of incident tuberculosis

May 9, 2025
Colchicine may lower the risk of cardiovascular events in patients with coronary disease
Chronic Disease

Motivational interviewing not effective in reducing rehospitalisation and improving patient activation among patients with respiratory failure

April 27, 2025
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Measles Outbreak, Tariffs and Healthcare, Pope’s Pneumonia, and Removing Fluoride from Water:

March 18, 2025
Next Post
Being overweight and obese associated with increased incidence of chronic kidney disease

Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease

Synthetic cannabinoid users more likely to use other illegal drugs

Computed tomography improves diagnostic certainty in the emergency department

Fewer off-road vehicle injuries with age-restricting legislation

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Sodium-glucose cotransporter 2 inhibitors may decrease risk of serious liver events in patients with cirrhosis
  • #VisualAbstract: Lactated Ringer’s Solution Does Not Improve Outcomes Relative to Normal Saline
  • 2MM: AI Roundup – FDA’s AI Push, Trial Speedups with Real-World Data, Smart Surgical Monitors, and Regulatory Overhaul Begins [July 2nd, 2025]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.