• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

Tramadol and Celecoxib effective pain control for hysteroscopy

byMaren ShapiroandLeah Hawkins Bressler, MD, MPH
December 6, 2015
in Obstetrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

 

1. Compared with placebo, patients who took Tramadol or Celecoxib experienced significantly reduced pain during and after hysteroscopy.

2. There was no significant difference in pain scores between the Tramadol and Celecoxib groups.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Hysteroscopy is the gold standard for diagnosing focal endometrial pathology that causes abnormal uterine bleeding and uterine factor infertility. The hysteroscopy procedure involves passage of a small camera through the cervical canal into the uterus to permit direct visualization of the endometrium. Previously, hysteroscopy was done in-patient under general anesthesia, but advancements such as use of smaller hysteroscopes allowed this procedure to be more cost-effective and to be performed as an outpatient. Despite these advancements, outpatient hysteroscopy can still be very uncomfortable and pain is been reported as a common cause of failure to complete the procedure. The body of literature on hysteroscopy pain control is robust, with many randomized controlled trials comparing various analgesics, including opioids, nonsteroidal anti-inflammatory drugs (NSAIDs), and local anesthesia. Despite this, in 2010, a Cochrane Review concluded there was insufficient evidence to support the use of oral analgesics, including NSAIDs and opioids, and recommended further study. In this randomized, double-blind, placebo-controlled trial, researchers compared the effectiveness of Tramadol (an opioid) and Celecoxib (a selective COX-2 inhibitor NSAID) at reducing pain associated with outpatient hysteroscopy.

Both Tramadol and Celecoxib were associated with significantly reduced pain during and after hysteroscopy compared with placebo. This is the first study to look at either oral Tramadol (as opposed to intramuscular or intravenous deliveries) and Celecoxib for hysteroscopy analgesia. Strengths of this study include the rigorous design. Limitations include small sample size (n=70) in each arm that limited power comparisons between tramadol and celecoxib. Larger studies are warranted.

Click to read the study in Human Reproduction

RELATED REPORTS

Expectant management of patent ductus arteriosus noninferior to early ibuprofen use

Abnormal menstruation may be associated with worse cardiometabolic outcomes later in life

Patients with early pregnancy loss less likely to receive active management in the emergency department

Relevant Reading: Pain relief for outpatient hysteroscopy

In-Depth [randomized controlled trial]: Women presenting for diagnostic outpatient hysteroscopy were randomized to receive one of three pain control treatment protocols 1 hour pre-procedure: oral Tramadol 100 mg (n = 70), oral Celecoxib 200 mg (n = 70), or oral placebo (n = 70). The primary outcome was pain perception during, immediately after and 30 minutes post-procedure as determined by the visual analogue scale (VAS). Secondary outcomes included time until no pain, side effects and complications.

Compared to women randomized to placebo, those who took pre-procedure Celecoxib and Tramadol groups experienced lower pain scores during, immediately after and 30 minutes post-procedure (p ≤ 0.001 for all comparisons). There was no difference in reported pain scores between women who received Tramadol and those who received Celecoxib group at all time points (p > 0.05 for all). Four women in the Tramadol group reported nausea; no women in the Celecoxib group reported side effects.

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: gynecologyHysteroscopynonsteroidal anti-inflammatory drug (NSAID)
Previous Post

Radiation dose associated with increased heart disease in Hodgkin lymphoma survivors

Next Post

Recurrence of endometrial hyperplasia following medical therapy is common

RelatedReports

Wide international variation in survival for periviable neonates
Cardiology

Expectant management of patent ductus arteriosus noninferior to early ibuprofen use

March 30, 2023
Cardiology

Abnormal menstruation may be associated with worse cardiometabolic outcomes later in life

March 28, 2023
American Academy of Pediatrics recommends standards for adverse event disclosures
Chronic Disease

Patients with early pregnancy loss less likely to receive active management in the emergency department

March 23, 2023
Variability in interpretation of breast biopsy slides associated with low verification of atypia and ductal carcinoma in situ
Weekly Rewinds

2 Minute Medicine Rewind February 13, 2023

February 13, 2023
Next Post
Recurrence of endometrial hyperplasia following medical therapy is common

Recurrence of endometrial hyperplasia following medical therapy is common

Adverse pregnancy outcomes associated with thrombophilias [Classics Series]

Cesarean delivery for term breech not associated with long-term benefit [Classics Series]

USPSTF finds insufficient evidence for screening for iron deficiency anemia during pregnancy

Inter-pregnancy weight gains linked to increased risks of stillbirth and infant mortality

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Expectant management of patent ductus arteriosus noninferior to early ibuprofen use
  • Exhaled volatile organic compounds predict bronchopulmonary dysplasia in preterm infants
  • Wellness Check: Mental Health
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options