• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Emergency

Unit-dose packaging of buprenorphine-naloxone associated with reduced pediatric unintentional exposures

byKate AndersonandLeah Carr, MD
May 3, 2018
in Emergency, Pediatrics, Psychiatry, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Pediatric unintentional opioid exposures decreased by more than 75% following the introduction of child-resistant unit-dose packaging (UDP).

2. More than 20% of unintentional buprenorphine-naloxone exposures in children <6 years were associated with moderate or severe outcomes.

 Study Rundown: In the past 2 decades, unintentional pediatric opioid poisonings have increased in parallel with the surge of opioid use among adults. Buprenorphine and combination buprenorphine-naloxone agents, commonly used to treat opioid dependence, are responsible for the majority of opioid-related pediatric hospitalizations. Previous studies have shown child-resistant UDP of these treatment agents is associated with reductions in pediatric emergency department visits for unintentional opioid exposure. In this study, investigators analyzed data from a national poison center reporting system to determine the effect of UDP on unintentional pediatric opioid exposures. Results showed pediatric unintentional opioid exposures packaging in children under the age of 6 years declined by more than 75% with use of UDP compared to traditional, non-UDP. More than 20% of patients reported moderate to severe effects from the opioid exposure and almost half of subjects were admitted to the hospital. This study is limited by reliance on caregiver and medical personal exposure reporting to poison centers which may underestimate the actual exposure rate. Results from this study suggest UDP may be an effective way to reduce pediatric healthcare facility visits, hospitalizations, and adverse outcomes related to unintentional opioid and other prescription medication exposures.

Click to read the study, published today in Pediatrics

Relevant reading: Adverse effects in children after unintentional buprenorphine exposure

In-depth [observational study]: Researchers analyzed data from 6217 combination buprenorphine-naloxone product exposures reported to 50 regional poison centers in 48 states from 2008 to 2016 in children <6 years old (51.7% male, median age 2 years). Exposures were split into 3 time periods to reflect changes in packaging use: pre-UDP (2008 to 2010), transition to UDP (2011 to 2012), and post-UDP (2013 to 2016). To account for increased buprenorphine-naloxone prescription rates, investigators calculated exposures per prescriptions dispensed. Results showed there was a 78.8% decrease in unintentional pediatric exposures from the pre-UDP to post-UDP periods (95% CI 76.1%-81.3%, p < .001) during the pre-UDP period, there were 20.57 exposures per 100 000 prescriptions dispensed, compared to 8.77 exposures during the transition to UDP period, and 4.36 exposures during the post-UDP period. A total of 1223 subjects (19.7%) reported moderate side-effects, 114 (1.8%) reported major effects, and 3 subjects died from exposure. About 47% of subjects were hospitalized with nearly half (23.2%) of those admitted to critical care units. There was no significant difference in exposure effect or disposition between the study time periods.

RELATED REPORTS

#VisualAbstract: Methadone is a Better Treatment for Opioid Use Disorder than Buprenorphine/Naloxone

#VisualAbstract: In Utero Exposure to Buprenorphine and Naloxone has Similar and More Favourable Outcomes Buprenorphine Alone

The Scan by 2 Minute Medicine®: FIFA Women’s World Cup, National Immunization Awareness Month, Back-to-School, Overdose Awareness, Maintenance of Certification Frustrations, and Wegovy for Weight Loss and the Heart

 Image: CC/Wiki/Soberconnections

©2018 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: burprenorphinenaloxoneopioid crisis
Previous Post

Computer analysis is not better than human clinical evaluation when it comes to measuring breast density

Next Post

Atropine plus propofol similar to atropine plus atracurium and sufentanil for non-emergent intubation in neonates

RelatedReports

#VisualAbstract: Methadone is a Better Treatment for Opioid Use Disorder than Buprenorphine/Naloxone
StudyGraphics

#VisualAbstract: Methadone is a Better Treatment for Opioid Use Disorder than Buprenorphine/Naloxone

November 4, 2024
#VisualAbstract: In Utero Exposure to Buprenorphine and Naloxone has Similar and More Favourable Outcomes Buprenorphine Alone
StudyGraphics

#VisualAbstract: In Utero Exposure to Buprenorphine and Naloxone has Similar and More Favourable Outcomes Buprenorphine Alone

August 26, 2024
The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: FIFA Women’s World Cup, National Immunization Awareness Month, Back-to-School, Overdose Awareness, Maintenance of Certification Frustrations, and Wegovy for Weight Loss and the Heart

August 22, 2023
The 2 Minute Medicine Podcast Episode 15
2MM Podcast

The 2 Minute Medicine Podcast Episode 21

August 10, 2023
Next Post
Rapid genetic testing useful for diagnosis of critically ill children

Atropine plus propofol similar to atropine plus atracurium and sufentanil for non-emergent intubation in neonates

Glyburide is not non-inferior to insulin in reducing perinatal complications in gestational diabetes

2 Minute Medicine Rewind December 31-January 6, 2013

2 Minute Medicine Rewind May 7, 2018

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Food compounds associated with disease activity in inflammatory bowel disease 
  • Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts
  • Volumetric diet and time-restricted eating demonstrate similar outcomes for weight reduction
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.