• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Use of cardiac stem cell factors linked with positive coronary bypass outcome

bys25qthea
November 22, 2013
in Cardiology, Chronic Disease, Surgery
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

Image: PD 

1. High circulating IGF-1 and several cardiac stem cell (CSC) markers correlate with positive ventricular remodeling after revascularization. 

2. High pre-op HGF and VEGF may protect damaged myocardium prior to revascularization. 

Evidence Rating Level: 2 (Good) 

Study Rundown: Long-term clinical outcomes of patients undergoing coronary artery bypass surgery are difficult to predict. Cardiac stem cells (CSCs) have for some time been implicated in cardiac remodeling, and there are a number of soluble factors known to affect their activity. The authors aimed to characterize the relationship among CSCs, circulating cytokines, and ventricular remodeling one year post-op in patients undergoing open coronary bypass. High circulating IGF-1 together with doubling time, IGF-1R expression, and telomerase in CSCs were found to predict ventricular remodeling. In addition, serum HGF and VEGF were significantly higher at baseline in the patients with positive remodeling. This study puts forth an interesting possibility for preoperative assessment of patients awaiting bypass surgery, though isn’t likely to affect surgical decision-making. However, it supports the development of stem cell therapeutic strategies and provides the foundation for a larger-scale evaluation of these biomarkers.

Click to read the study in Circulation

Relevant Reading: Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression

RELATED REPORTS

History of adverse pregnancy outcomes associated with image-identified coronary artery disease

#VisualAbstract: Prophylactic methylprednisolone for cardiac surgery in infants does not improve post-operative outcomes

Prophylactic methylprednisolone for cardiac surgery in infants does not improve post-operative outcomes

In-Depth [prospective cohort study]: The study enrolled 55 patients undergoing elective coronary artery bypass surgery, 17 of whom were lost at follow-up. The right atrial appendage was harvested for CSCs. At the time of surgery and at 12 +/- 1 months, patients had 2-D echocardiography, and labs for serum IGF-1, HGF, VEGF, SCF, G-CSF, and bFGF. CSCs were selected for with c-kit at P5 or P6 by FACS and telomere length as measured by flow-FISH with high telomerase activity. Indicators of CSC growth were correlated with improved echographic findings: decrease in chamber volume and increase in ventricular mass, mass-to-chamber volume ratio, and LV ejection fraction. Patients were then divided into two groups, based on an increase in LV end-diastolic volume of >= or < 20%. Positively-remodeled hearts were found to have shorter population doubling time, longer telomeres, and higher telomerase and IGF-1R activity. Multivariate analysis confirmed statistically significant association of CSC growth variables with LV remodeling.

By Mariya Samoylova and Allen Ho

More from this author: Endovascular repair of ruptured AAAs no better than open repairTransfusion worsens outcomes for HCV+ liver transplant recipientsResident involvement linked with more complications in joint surgeryPromising liver transplant outcomes at 20 yearsHopkins frailty score is best predictor of postoperative complications

©2012-2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

Tags: CABGCoronary artery diseasecoronary bypass
Previous Post

Pediatric appendicitis outcomes in Canada not superior to US

Next Post

Phthalate exposure during pregnancy associated with preterm birth

RelatedReports

SARS-CoV-2 is associated with higher incidence of Kawasaki disease in children
Cardiology

History of adverse pregnancy outcomes associated with image-identified coronary artery disease

February 16, 2023
#VisualAbstract: Prophylactic methylprednisolone for cardiac surgery in infants does not improve post-operative outcomes
StudyGraphics

#VisualAbstract: Prophylactic methylprednisolone for cardiac surgery in infants does not improve post-operative outcomes

January 5, 2023
Large proportion of late preterm infants and older admitted to the NICU
Cardiology

Prophylactic methylprednisolone for cardiac surgery in infants does not improve post-operative outcomes

December 22, 2022
#VisualAbstract: Functional testing nonsuperior to routine care for percutaneous coronary intervention patients
StudyGraphics

#VisualAbstract: Functional testing nonsuperior to routine care for percutaneous coronary intervention patients

September 14, 2022
Next Post
Antepartum and intrapartum events both linked to neonatal HIE

Phthalate exposure during pregnancy associated with preterm birth

Breastfeeding associated with decreased risk of childhood obesity

Educational intervention increases breastfeeding duration in minorities

Increased frailty associated with childhood cancer survivorship

Increased frailty associated with childhood cancer survivorship

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • SAR-CoV-2 infection during pregnancy may lead to adverse neurodevelopmental outcomes in male offspring
  • Hyperfractionated radiotherapy reduces complication rates compared to standard fractionation for locally advanced nasopharyngeal carcinoma
  • Lebrikizumab effective in treating moderate-to-severe atopic dermatitis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options