• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Variability in interpretation of breast biopsy slides associated with low verification of atypia and ductal carcinoma in situ

byCaitlyn HuiandSai Folmsbee
March 21, 2016
in Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. High agreement between individual pathologists and reference consensus diagnoses was observed for the verification of invasive breast cancer and benign without atypia.

2. Variability in pathologists’ interpretations led to overdiagnoses of atypia and ductal carcinoma in situ when compared to reference consensus diagnoses.

Evidence Rating Level: 2 (Good)

Study Rundown: The Breast Pathology Study evaluates diagnostic agreement between pathologists in their interpretation of breast biopsy slide specimens. This analysis aimed to apply the results to patient populations by estimating how diagnostic variability affects accuracy of breast biopsy specimen interpretation. Generally, the authors observed that the vast majority of individual pathologist interpretations of breast biopsy specimens of women included in the study would likely agree with the interpretations of the reference consensus panel. High accuracy was observed among women diagnosed with benign without atypia and invasive breast cancer. However, significant variation was observed among diagnoses of atypia and ductal carcinoma in situ (DCIS), where both were overdiagnosed by individual pathologists when compared to the reference. This study is limited by several factors. First, although the reference consensus panel was composed of three expert opinions, there is no guarantee that this panel represents a truly accurate diagnosis. Furthermore, as this analysis assessed women screened using film mammography, results may differ with newer technologies. Overall, this study highlights that while interpretation of invasive breast cancer and benign cases without atypia are highly accurate, reference diagnosis verification for DCIS and atypia may be much lower.

Click to read the study published today in the Annals of Internal Medicine

Relevant Reading: Diagnostic Concordance Among Pathologists Interpreting Breast Biopsy Specimens

RELATED REPORTS

The Scan by 2 Minute Medicine®: Celebrity diagnoses spur screenings, athlete mental-health push, reality-TV heart lesson, and a sitcom PSA wave

Breast cancer survivors may have a lower risk of Alzheimer’s dementia

Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts

In-Depth [population study]: In this study, the authors assessed the probability that a pathologist’s interpretation of a single diagnostically representative breast biopsy slide would accord with a consensus-based reference standard derived from 3 expert breast pathologists interpreting the same slide. The predictive values were calculated with Bayes’ theorem, utilizing results from the Breast Pathology Study, as well as published data on the prevalence of breast pathology diagnoses in women aged 50 to 59 from the Breast Cancer Surveillance Consortium. It was observed that confirmation of pathologists’ interpretations by the expert reference consensus panel would occur in 92.3% (95%CI 91.4% to 93.1%) of biopsies overall. Furthermore, for women receiving a diagnosis of benign without atypia or invasive breast cancer, the analysis indicated 97.1% (95%CI 96.7% to 97.4%) and 97.7% (95%CI 96.5% to 98.7%) diagnostic agreement, respectively, between individual pathologists and the reference panel. In contrast, only 37.8% accordance was observed for diagnoses of atypia (95%CI 33.6% to 42.7%) and 69.6% for DCIS (95%CI 64.4% to 75.3%).

Image: CC/Wiki

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Breast CancerDCIS
Previous Post

No long-term outcome differences between stenting versus surgery for carotid stenosis

Next Post

Covered self-expanding metallic stents noninferior to plastic stents in benign biliary strictures

RelatedReports

The Scan by 2 Minute Medicine®:  Ultra-Trail du Mont-Blanc, Taylor Swift, NBA rookie Chet Holmgren and Magic Mushrooms!
The Scan by 2 Minute Medicine®

The Scan by 2 Minute Medicine®: Celebrity diagnoses spur screenings, athlete mental-health push, reality-TV heart lesson, and a sitcom PSA wave

July 2, 2025
Chronic Disease

Breast cancer survivors may have a lower risk of Alzheimer’s dementia

July 2, 2025
3D mammography (tomosynthesis) enhances accuracy of breast cancer screening
Chronic Disease

Abbreviated MRI is superior to whole-breast ultrasound for detection of cancer in dense breasts

June 25, 2025
#VisualAbstract: Elinzanetant Effectively Reduces Vasomotor Symptoms from Endocrine Therapy for Breast Cancer
StudyGraphics

#VisualAbstract: Elinzanetant Effectively Reduces Vasomotor Symptoms from Endocrine Therapy for Breast Cancer

June 17, 2025
Next Post
Covered self-expanding metallic stents noninferior to plastic stents in benign biliary strictures

Covered self-expanding metallic stents noninferior to plastic stents in benign biliary strictures

Smoking during pregnancy associated with aerobic fitness of children

Post-partum concern-focused smoking cessation intervention not effective at reducing relapse

Increasing C-section room temperature linked to reduced neonatal, maternal hypothermia

Early antibiotic exposure not linked with childhood weight gain

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Seventh cervical nerve neurotomy may augment speech therapy in patients with chronic aphasia post-stroke
  • Time-restricted eating does not confer changes in sleep, mood, or quality of life
  • Commonly cited medication triggers may not increase risk of microscopic colitis among older adults
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.