• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Vitamin D, calcium not linked with reduced recurrent colorectal adenomas

byShaidah Deghan, MSc. MD
October 15, 2015
in Chronic Disease, Gastroenterology, Oncology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

 

1. Daily consumption of neither vitamin D3 nor calcium, alone or in combination, reduced the risk of recurrent colorectal adenomas.

2. The study draws strengths from its large number of participants, high adherence, low exogenous vitamin intake but is limited due to selecting a lower dose than the current vitamin D intake level guidelines.

Evidence Rating Level: 1 (Excellent)      

Study Rundown: Previous studies have shown that vitamin D and high calcium intake are associated with antineoplastic and lower risks of colorectal neoplasia respectively. This study investigated the chemopreventive potential of vitamin D and calcium for the prevention of new colorectal adenomas in persons with a recent history of adenomas. A total of 2259 participants with recently diagnosed adenomas were randomly assigned to receive either daily vitamin D3 (1000 IU), calcium as carbonate (1200 mg), both or neither in a partial 2×2 factorial design. The study found that daily supplementation did not result in any significant reduction in risk of recurrent colorectal adenomas over the 3-5 year follow-up period. The trial was sufficiently large enough to detect modest chemopreventive effects. Adherence to the study treatment was high and the number of participants that dropped out, were lost to follow-up, or died were minimal (4.6%).

Click to read the study, published today in NEJM

Relevant Reading: Long-Term Follow-Up for Mortality and Cancer in a Randomized Placebo-Controlled Trial of Vitamin D3 and/or Calcium (RECORD Trial)

RELATED REPORTS

Vitamin D supplementation does not improve mental outcomes in adults with early psychosis

Wellness Check: Nutrition

Vitamin D supplementation not supported to treat first-episode psychosis

In-Depth [randomized controlled trial]: This was a randomized, multicenter, double-blind, placebo-controlled trial. A total of 2259 participants underwent randomization and received either 1000 IU of vitamin D3, 1200mg of calcium as carbonate, both agents, or placebo. Participants were expected to continue on with the study treatment until the anticipated 3-year or 5-year colonoscopic examination. Primary end points included all adenomas that were diagnosed in any colorectal endoscopic or surgical procedure at least 1 year after randomization and up to 6 months after the anticipated 3 or 5 year colonoscopic examination. Only 4.6% of the participants dropped out of the study, were lost to follow-up, or died. The adjusted RR for any adenoma among patients taking vitamin D vs. those not taking vitamin D was 0.99 (95%[CI] 0.89-1.09). Adjusted RR among patients taking calcium compared to those not taking calcium was 0.95 (95% [CI], 0.85-1.06). The adjusted RR among patients taking vitamin D plus calcium versus those taking neither agent was 0.93 (95% [CI], 0.80 to 1.08). There were no significant effects of supplementation in subgroup analyses. However, there was a significant association between BMI and calcium effect on adenoma risk.

Image: PD 

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: calciumcolon cancervitamin d
Previous Post

Contamination during personal protective equipment removal may be common

Next Post

Dietary supplements linked to 23,000 emergency visits per year

RelatedReports

Multiple opioid prescriptions associated with higher hospital admissions
Psychiatry

Vitamin D supplementation does not improve mental outcomes in adults with early psychosis

February 22, 2022
Provision of medically-tailored meals linked with lower admissions and medical spending
Wellness

Wellness Check: Nutrition

February 17, 2022
Implementation of pneumococcal vaccine programs linked to decreased antibiotic prescription
Chronic Disease

Vitamin D supplementation not supported to treat first-episode psychosis

February 22, 2022
Cardiology

Calcium does not significantly improve return of spontaneous circulation in adults with out-of-hospital cardiac arrest

December 3, 2021
Next Post
AAP issues update on iodine deficiency and associated pollutants

Dietary supplements linked to 23,000 emergency visits per year

Recurrent hemoptysis is effectively treated by bronchial artery embolization

Recurrent hemoptysis is effectively treated by bronchial artery embolization

No decrease in infant mortality with maternal micronutrient supplementation in Bangladesh

Budesonide linked with decreased bronchopulmonary dysplasia in preterm infants

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Segmentectomy is superior to lobectomy for patients with early-stage non-small cell lung cancer
  • Several factors influence health programs conducted in the African American Church
  • Imiquimod noninferior to surgery in management of vulvar high-grade squamous intraepithelial lesions
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.