Tag: colon cancer

1. Explicit emulation of a target trial investigating the comparative efficacy of a shortened duration of adjuvant chemotherapy in individuals with stage III colon cancer was found to be noninferior to the standard 6-month regimen, consistent with results from the International Duration Evaluation of Adjuvant (IDEA) trial. 2. In contrast,...
1. In a phase 3 trial across 23 countries, Pembrolizumab displayed a longer cancer-free period when compared to the first line therapy for metastatic microsatellite instability or mismatch-repair deficiency (MSI-H-dMMR) colorectal cancer. Evidence Rating Level: 1 (Excellent) Study Rundown: A subset of colorectal cancer tumors is mismatch-repair deficiency (dMMR) which has been known...
1. Adding bevacizumab to mFOLFOX6 therapy among patients with RAS mutant metastatic colorectal cancer led to an increased rate of liver metastases resection, which has previously been demonstrated to improve survival. 2. Bevacizumab addition to standard therapy was associated with increased overall survival and progression-free survival at three years. Evidence Rating...
1. A shortened course of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer was associated with decreased peripheral sensory neuropathy without compromising effectiveness. Evidence Rating Level: 1 (Excellent) FOLFOX4 regimen, which includes oxaliplatin, has proven efficacy in both the metastatic colorectal cancer setting and the adjuvant setting for resected stage III...
Efficacy and Long-term Peripheral Sensory Neuropathy of 3 vs 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Colon Cancer: The ACHIEVE Phase 3 Randomized Clinical Trial 1. A shortened course of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer was associated with decreased peripheral sensory neuropathy without compromising effectiveness. Evidence Rating Level:...
The most common colorectal cancer (CRC) screening methods are colonoscopy, flexible sigmoidoscopy (FS), and fecal immunochemical testing (FIT). The diagnostic yield of any screening method is dependent on participation, and endoscopic screening consistently shows lower participation rates compared to FIT-based screening. In this analysis of three randomized studies, 30,052...
Pregnancy duration and endometrial cancer risk: nationwide cohort study Full-term pregnancies are strongly associated with a reduced risk of endometrial cancer. Whether this protective association is driven by fecundity, a specific process that occurs during pregnancy, or cumulative number of months pregnancy, however, is unknown. In this cohort study, 2,311,332...
1. In this randomized controlled trial, single dose aspirin given two days prior to fecal immunochemical testing (FIT) did not increase test sensitivity for detection of colorectal cancer at 2 predefined cutoffs. 2. Study findings contrast with previous observational studies that showed increased sensitivity of FIT in users of low-dose...
1. Patients with advanced adenomas identified on flex sigmoidoscopy had a significantly increased risk of death from colorectal cancer (CRC) compared to those with no adenomas. 2. There was no difference in cumulative CRC incidence in patients with nonadvanced adenomas as compared to those with no adenomas. Evidence Rating: 1 (Excellent) Study...
1. BEACON CRC is a multicenter, randomized, phase 3 clinical trial evaluating the triplet combination of binimetinib (BINI, a MEK inhibitor) + encorafenib (ENCO, a BRAF inhibitor) + cetuximab (CETUX, an EGFR antibody) for the treatment of metastatic colorectal cancer. 2. Preliminary analysis of the Safety Lead-in Study for the...