Tag: colon cancer

1. In this randomized controlled trial, cetuximab or bevacizumab combined with platin therapy had similar survival rates for patients with KRAS wildtype, advanced, or metastatic colorectal cancer. 2. Response rates and progression free survival were also equivocal for both groups of patients. Evidence Rating Level: 1 (Excellent) Study Rundown: Though platin therapy...
1. In this study, interval colorectal cancer diagnoses were significantly higher in black patients compared to white patients. 2. The disparity between ethnicities was more pronounced for cancer of the distal colon and rectum. Evidence Rating Level: 2 (Good) Study Rundown: Colorectal cancer (CRC) is a significant health concern. As the third...
  Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults Obesity is known to exacerbate age-related decline in physical function. In older adults, associated reductions in muscle and bone mass place patients at risk of frailty. Exercise has been shown to improve physical functioning in older adults and reduce...
1. In this randomized control trial, an intervention directed towards improving education and reducing barriers to colorectal cancer screening in vulnerable populations was associated with improved screening rates at 6 months. 2. Women were more likely to have improved screening rates than men exposed to the same intervention. Evidence Rating Level:...
1. This study estimates that the 8-year risk for colorectal cancer (CRC) in Medicare beneficiaries was reduced by screening colonoscopy from 2.6% to 2.2% in those 70-74 years of age and from 3.0% to 2.8% in those 75-79 years of age. 2. These results could assist patients, doctors, and...
1. Based on the initial analysis of this population-based randomized clinical trial addressing screening colonoscopies in several European countries, the results showed a positive outcome in regards to the adenoma and cancer detection rates. However, there was significant variability in participation rates and endoscopists’ performance. 2. The most common side...
1. Nanoparticle delivery of the aurora kinase inhibitor AZD2811 led to sustained drug retention in a rat model of colon adenocarcinoma. 2. As compared to treatment with the free, soluble form of AZD2811, nanoparticle administration significantly decreased tumor size and delayed the onset of tumor regrowth. Evidence Rating Level: 2...
  1. The expression status of biomarker CDX2 was identified as an independent prognosticator in stage II and III colon cancer (CC). 2. CDX2-negative CC had a lower 5-year disease free survival rate compared to CDX5-positive CC, while a higher 5-year disease free survival rate was observed in CDX2 negative...
Neonatal glycemia and neurodevelopmental outcomes at 2 years Neonatal hypoglycemia is common and when prolonged may result in brain injury. The effect of acute and brief hypoglycemia on neurologic development, however, has not yet been well defined. To investigate the relationship between low glucose concentrations in the neonatal period and...
  1. Daily consumption of neither vitamin D3 nor calcium, alone or in combination, reduced the risk of recurrent colorectal adenomas. 2. The study draws strengths from its large number of participants, high adherence, low exogenous vitamin intake but is limited due to selecting a lower dose than the current...