• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Neurology

Treating subclinical hypothyroidism and hypothyroxinemia in pregnancy does not impact child IQ

byShaidah Deghan, MSc. MD
March 9, 2017
in Neurology, Obstetrics, Pediatrics, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In pregnant women, treating subclinical hypothyroidism or hypothyroxinemia with levothyroxine did not significantly impact cognitive outcomes in children up to age 5 years of age when compared to placebo.

2. No significant adverse maternal or fetal/neonatal events were described as a result of treatment.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Adverse outcomes, such as lower intelligence quotient (IQ), have been associated with subclinical hypothyroidism during pregnancy. Treatment of subclinical hypothyroidism in pregnant women with levothyroxine remains an area of controversy. The primary objective of this study was to assess the effects of screening for hypothyroidism and levothyroxine replacement during pregnancy on cognitive outcomes of children at 5 years of age for women with either subclinical hypothyroidism or hypothyroxinemia. Women who completed the adherence run-in phase were randomized to receive placebo or levothyroxine. In summary, the study demonstrated no significant difference between the levothyroxine and placebo groups with regards to the childrens’ median IQ.

Click to read the study, published in NEJM

Relevant Reading: AOGS Practice Bulletin No. 148: Thyroid Disease in Pregnancy

In-Depth [randomized controlled trial]: This was a parallel, multicenter, randomized, placebo-controlled trial that included women diagnosed with subclinical hypothyroidism and hypothyroxinemia through screening tests. Subclinical hypothyroidism was defined as having a thyrotropin level >4.00 mU/liter and a normal free thyroxine (T4) level (0.86 to 1.90 ng/dL). Hypothyroxinemia was defined as having a normal thyrotropin level (0.08 to 3.99 mU/L) and a low free T4 level (<0.86 ng/dL).

RELATED REPORTS

Nasal high-flow therapy improves likelihood of neonatal intubation

Treating mild chronic hypertension associated with better pregnancy outcome

Prenatal medication for opioid use disorder helps discharge infants back to mothers

A total of 677 women with subclinical hypothyroidism and 526 women with hypothyroxinemia were randomized to either placebo or levothyroxine treatment. The primary outcome was a child’s full-scale IQ assessed using multiple standardized scoring systems, such as the Wechsler Preschool and Primary Scale of Intelligence III (WPPSI-III) at 5 years of age. Alternatively,  the Differential Ability Scales–II (DAS) at 3 years of age was also considered, if the WPPSI-III score was not available. Secondary outcomes included the cognitive, motor, and language scores on the Bayley Scales of Infant Development, Third Edition (Bayley-III), at 12 months and 24 months of corrected age for each child.

The median IQ score of the children in the subclinical hypothyroid group was 97 (95%CI 94 to 99) in the levothyroxine group and 94 (95%CI 92 to 96) in the placebo group (p = 0.71). The median IQ score was 94 (95%CI 91 to 95) in the levothyroxine group and 91 (95%CI 89 to 93) in the placebo group for the hypothyroxinemia group (p = 0.30). There were no significant differences between the groups in terms of adverse maternal or fetal/neonatal outcomes, including pre-term birth, placental abruption, gestational hypertension, stillbirth/miscarriage rates, and neonatal death.

Image: CC/Wiki

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: Hypothyroidismneonatalpregnancy
Previous Post

Imatinib safe and effective as long-term treatment for chronic myeloid leukemia: The IRIS trial

Next Post

Ischemic stroke from cervical artery dissection associated with history of migraine

RelatedReports

Low evidence for glycerin use in preterm infants
Obstetrics

Nasal high-flow therapy improves likelihood of neonatal intubation

May 13, 2022
Prenatal antidepressant exposure may increase risk of poor motor development
Cardiology

Treating mild chronic hypertension associated with better pregnancy outcome

May 13, 2022
Prenatal antidepressant exposure may increase risk of poor motor development
Chronic Disease

Prenatal medication for opioid use disorder helps discharge infants back to mothers

April 22, 2022
Quick Take: Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial
Wellness

Wellness Check: Addictions

April 21, 2022
Next Post
Intensive rehabilitation not superior to traditional therapy for arm function after stroke

Ischemic stroke from cervical artery dissection associated with history of migraine

Standardized developmental screening of refugee children is recommended

AAP endorses humane treatment of all immigrant children

Imatinib safe and effective as long-term treatment for chronic myeloid leukemia: The IRIS trial

2 Minute Medicine Rewind March 13, 2017

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Wellness Check: Mental Health
  • #VisualAbstract: Addition of elotuzumab to lenalidomide and dexamethasone did not significantly improve survival outcomes in newly diagnosed, transplant-ineligible multiple myeloma
  • #VisualAbstract: Pretreatment with radiotherapy and two cycles of concurrent cisplatin may reduce toxicity in locally advanced nasopharyngeal carcinoma
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.