• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Adolescents with type II diabetes have more complications than those with type I

byMichael MilliganandDaniel Fisher
March 1, 2017
in Chronic Disease, Endocrinology, Pediatrics, Public Health
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In this prospective cohort, adolescents with type II diabetes (DM2) were more predisposed to almost every diabetes related complication at age 21 than those with type I diabetes (DM1).

2. When controlling for known risk factors, such as obesity and glycemic control, those with DM2 still had a higher rate of diabetic kidney disease, retinopathy, and peripheral neuropathy than those with DM1.

Evidence Rating Level: 2 (Good)

Study Rundown: The prevalence of DM1 and DM2 has been rising in pediatric populations over time. Understanding how these diseases lead to complications and comorbidities is essential. Despite their similarities, DM1 and DM2 represent distinct pathogenic mechanisms, and it is unclear whether specific environmental risk factors drive morbidity in one disease over the other. In this prospective, cross-sectional cohort analysis, adolescents from 5 major US cities with DM1 or DM2 were followed until age 21, and their rates of complications and comorbidities were recorded. While mean HbA1c were similar between groups, those with DM2 developed diabetic kidney disease, retinopathy, peripheral neuropathy, arterial stiffness, and hypertension at a greater rate than those with DM1. Cardiovascular autonomic neuropathy rates were similar between groups. In addition, those with DM2 had higher rates of obesity and elevated mean arterial pressure over time. After controlling for these multiple risk factors and others, those with DM2 still had higher rates of diabetic kidney disease, retinopathy, and peripheral neuropathy, though the changes in arterial stiffness and hypertension were attenuated to non-significant levels.

This study convincingly shows that adolescents with DM2 are more likely to develop complications associated with diabetes, and the data hints that environmental factors may not be the sole cause of this difference. Based on this study, more focused investigations into the pathogenesis of DM1 and DM2 should begin to search for mechanistic differences that may explain the differences in complication rates between these two diseases.

Click to read the study, published today in JAMA

Relevant Reading: Prevalence of Type 1 and Type 2 Diabetes Among Children and Adolescents From 2001 to 2009

RELATED REPORTS

Adverse childhood experiences may be associated with sleep disorders in post-secondary students

Childhood insomnia symptoms may persist into adulthood

Faricimab may improve visual acuity in patients with diabetic macular edema

In-Depth [prospective cohort]: In 5 US cities, 2018 adolescents under the age of 20 were followed until age 21 in the SEARCH for Diabetes in Youth registry study. Those with DM2 were older at time of diagnosis, were more likely female, and more likely from minority groups than those with DM1. Other demographic data were similar. While those with DM2 had higher measures of obesity and mean arterial pressure, HbA1c counts were similar between groups. Those with DM2 were more likely to have diabetic kidney disease (absolute difference 14.0%; CI95 9.1%-19.9%), retinopathy (3.5%; CI95 0.4%-7.7%), peripheral neuropathy (9.2%; CI95 4.8- 14.4%), arterial stiffness (35.9%; CI95 29%-42.9%), and hypertension (11.5%; CI95 6.8%- 16.9%) without a change in cardiac autonomic neuropathy (p > 0.05). Adjustments for age or race did not attenuate the differences between groups. A final model accounting for hemoglobin A1c level, BMI, waist-height ratio, and mean arterial pressure averaged over time attenuated the findings for arterial stiffness and hypertension non-significant levels, though all other associations remained significantly elevated in DM2.

 

Image: PD

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: diabetes mellituspediatric
Previous Post

 Transgender adolescents report less sexual activity than non-transgender peers

Next Post

Lower doses of radiation for pediatric cancers associated with fewer subsequent cancers

RelatedReports

Standardized developmental screening of refugee children is recommended
Pediatrics

Adverse childhood experiences may be associated with sleep disorders in post-secondary students

May 31, 2022
Adolescent mothers in protective care more likely to have their children placed in care
Pediatrics

Childhood insomnia symptoms may persist into adulthood

April 19, 2022
Blindness and visual impairment decreasing worldwide
Chronic Disease

Faricimab may improve visual acuity in patients with diabetic macular edema

March 8, 2022
Insulin costs rose exponentially, regardless of formulation or patent
Cardiology

Supplementation of tirzepatide for type 2 diabetics on basal insulin improved glycemic control compared to placebo

February 9, 2022
Next Post
Ovarian cytology a poor screening test for malignancy in children

Lower doses of radiation for pediatric cancers associated with fewer subsequent cancers

Computed tomography improves diagnostic certainty in the emergency department

Most children needing end-of-life care receive it in acute care settings

Ultrasound enhances gastrointestinal absorption of drugs at low frequencies

Reminder devices may not improve medication adherence: The REMIND trial

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Cognitive behavioral therapy efficacious for treatment of comorbid posttraumatic headache and posttraumatic stress disorder symptoms among US veterans
  • Sickle cell trait associated with preexisting kidney comorbidities and increased COVID-19 mortality
  • Adding atezolizumab to standard of care treatment for human epidermal growth factor receptor 2 (HER2) positive early breast cancer does not improve pathologic response outcomes
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.