• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Oncology

Analysis of early-onset colorectal cancer incidence by age, subsite, and histologic subtype

byThomas SuandDeepti Shroff Karhade
January 28, 2021
in Oncology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. While carcinoids contribute more heavily to the total incidence of early-onset colorectal cancer than they did in 2000, adenocarcinomas have also become more prevalent in nearly all subgroups.

2. Younger patients are experiencing the greatest growth in incidence rate, highlighting the necessity of risk-stratification and early diagnostic testing.

Evidence Rating Level: 2 (Good)

Study Rundown: Colorectal cancer is the third leading cause of cancer death in the United States, with a lifetime risk of roughly 1 in 25 in both men and women. While the overall incidence of colorectal cancer has been decreasing for the past several decades according to SEER data, detected cases of early-onset colorectal cancer (EOCRC) have instead been steadily rising in number. Previous analyses have generally focused on overall CRC incidence with little emphasis on specific histological subtypes. However, identification of the fastest-growing cancer types and the highest risk groups is critical in order to better inform the potential modification of controversial screening guidelines. This retrospective study found that, while the two youngest age groups still had the lowest absolute incidence rates, they also experienced the steepest increase in rectal adenocarcinoma. While adenocarcinoma comprised the bulk of CRC cases throughout the study, these changes were generally overshadowed by the increase in carcinoid tumors across all age groups, resulting in an increased contribution to the total number of CRC cases over time. It is unclear whether these trends can be attributed to a true increase in tumors due to lifestyle factors or simply to advances in endoscopic detection, but the results of this study reflected the importance of maximizing screening efforts in older and higher-risk individuals. Further, the finding that adenocarcinomas were found to be increasing in the most early-onset subgroups had implications for the adjustment of the average-risk screening age from 50 to 45 years.

Click here to read the study, published today in Annals of Internal Medicine

Click here to read an accompanying editorial, published today in Annals of Internal Medicine

Relevant Reading: Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975-2010

RELATED REPORTS

Pembrolizumab did not show overall survival benefit in patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer

Addition of atezolizumab to capecitabine + bevacizumab is not clinically beneficial in the treatment of refractory metastatic colorectal cancer

Higher abundance of dietary sulfur-reducing microbes was associated with increased risk of colorectal cancer

In-Depth [retrospective cohort]: This study utilized SEER 18 data from 2000 to 2016 to examine all CRC cases in patients between the ages of 20 and 54 years. To minimize the effects of short-term fluctuations in incidence rate, rate comparisons were generated using a three-year average for the study period flanks (2000-2002 and 2014-2016). While the two younger age groups had manifold fewer cases overall compared to the two older age groups (16131 versus 107012 cases), they also had the greatest change in adenocarcinoma incidence. Specifically, there were increases of 39% in rectal-only cases in both patients aged 20-29 years (0.33 to 0.46 per 100,000) and those aged 30-39 years (1.92 to 2.66 per 100,000); colon-only cases in those aged 30-39 years also increased by 20% (3.30 to 3.97 per 100,000). Smaller increases in the range of 10-16% were also observed in the 40-49 and 50-54 age groups. The only categories that did not display a statistically significant gain in adenocarcinoma incidence over time were colon-only cases in the youngest age group and both colon-only and colorectal cases in the oldest. On the other hand, rectal carcinoid tumors increased significantly in all age groups, with the steepest changes occurring in those aged 20-29 (113% [0.08 to 0.17 per 100,000]) and those aged 50-54 (+159% [2.36 to 6.10 per 100,000]).

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: adenocarcinomacolorectal cancer
Previous Post

Self-obtained vaginal swabs for Neisseria gonorrhoeae and Chlamydia trachomatis found to be non-inferior to provider administrated sampling

Next Post

#VisualAbstract: Prognosis for advanced melanoma has improved between 2013 to 2017 for patients in the Netherlands

RelatedReports

Oophorectomy associated with reduced cancer risk and all-cause mortality for BRCA1/2 patients
Oncology

Pembrolizumab did not show overall survival benefit in patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer

April 18, 2022
Noninvasive imaging method detects and evaluates size of metastases
Chronic Disease

Addition of atezolizumab to capecitabine + bevacizumab is not clinically beneficial in the treatment of refractory metastatic colorectal cancer

February 25, 2022
Normal renal ultrasound only rules out high grade vesicoureteral reflux in infants
Gastroenterology

Higher abundance of dietary sulfur-reducing microbes was associated with increased risk of colorectal cancer

January 4, 2022
Provision of medically-tailored meals linked with lower admissions and medical spending
Wellness

Wellness Check: Nutrition

December 30, 2021
Next Post
#VisualAbstract: Margetuximab improves progression-free survival in patients with ERBB2⁺ advanced breast cancer compared to trastuzumab

#VisualAbstract: Prognosis for advanced melanoma has improved between 2013 to 2017 for patients in the Netherlands

#VisualAbstract Lenalidomide shows improvement in progression-free survival over bortezomib maintenance following autologous stem cell transplantation for multiple myeloma

#VisualAbstract Lenalidomide shows improvement in progression-free survival over bortezomib maintenance following autologous stem cell transplantation for multiple myeloma

Rilonacept may lower pericarditis recurrence in patients with relapsing pericarditis

Machine learning-based PRAISE score may aid in the prediction of adverse events following an acute coronary syndrome

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Severe actinic keratosis and need for additional treatment are markers for an increased risk of cutaneous squamous cell carcinoma
  • Virtual yoga and meditation intervention may be associated with increased health-related quality of life
  • Wellness Check: Mental Health
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.