• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Emergency

Blood transfusions from female, previously pregnant, or sex-discordant donors do not increase mortality

byJason Nam, MDandDaniel Fisher
June 11, 2019
in Emergency, Obstetrics, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this large retrospective cohort, there were no increases in mortality from red blood cell transfusions from female, previously pregnant, or sex-discordant donors.

Evidence Rating Level: 2 (Good)

Study Rundown: Recently, a few studies have suggested that blood donation from female donors, especially to male recipients, may result increased adverse events, such as transfusion-related acute lung injury. However, though an uptick in these events may be associated with antibody-mediated mechanisms, it is unclear if there is an increased mortality risk under these situations. Analyzing data from 3 large cohorts, red blood cell transfusions from female, sex-discordant, and previously pregnant donors did not result in a dose-dependent increases in mortality.

Though this study suggests that sex is not a significant factor in determining mortality from transfusions, some limitations should be noted. First, while there were no significant associations between any of the donor exposures and mortality, there may have been an association with other adverse outcomes, such as hospital length of stay or frequency of non-fatal adverse events. Further, the study did not account for blood components other than red blood cells.

Click to read the study, published today in JAMA

Relevant Reading: Association of Blood Transfusion From Female Donors With and Without a History of Pregnancy With Mortality Among Male and Female Transfusion Recipients.

In-Depth [retrospective cohort]: Data from 3 retrospective cohorts of transfusions in the United States and Scandinavia was used and analyzed. In-hospital mortality was the primary outcome, and long-term mortality was a secondary outcome. There were no significant associations between any of the 3 donor exposures and in-hospital mortality in the 3 cohorts. Specifically, hazard ratios for in-hospital mortality per transfused unit from female donors were 0.99 (CI95 0.96 to 1.03) for the Kaiser Permanent cohort, 1.00 (CI95 0.99 to 1.01) for the US hospitals cohort, and 1.00 (CI95 0.99 to 1.00) for the Scandinavian cohort. For units from previously pregnant or parous female donors, hazard ratios were 1.00 (CI95 1.00 to 1.01) for the Kaiser Permanente cohort, 1.01 (CI95 0.98 to 1.03) for a US hospitals cohort, and 1.00 (CI95,1.00 to 1.01) for the Scandinavian cohort. For units from sex-discordant transfusions, hazard ratios were 1.02 (CI95 0.99 to 1.05) for the Kaiser Permanente cohort, 0.99 (CI95 0.98 to 1.00) for a US hospitals cohort, and 1.00 (CI95 0.99 to 1.00) for the Scandinavian cohort.

RELATED REPORTS

#VisualAbstract: Resuscitation with blood products was not superior to 0.9% sodium chloride in patients with trauma-related haemorrhagic shock receiving pre-hospital care

#VisualAbstract ESCORT-HU highlights the real-life positive benefit-to-risk ratio of hydroxyurea in patients with sickle cell disease

#VisualAbstract: Immediate Transfusion in African Children with Uncomplicated Severe Anemia

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: blood donorblood transfusionpacked red blood cells (PRBCs)transfusion reaction
Previous Post

Quick Take: Ultra-processed food intake and risk of cardiovascular disease

Next Post

Differences in presenting emergency department symptoms for inhaled vs edible cannabis use

RelatedReports

#VisualAbstract: Resuscitation with blood products was not superior to 0.9% sodium chloride in patients with trauma-related haemorrhagic shock receiving pre-hospital care
StudyGraphics

#VisualAbstract: Resuscitation with blood products was not superior to 0.9% sodium chloride in patients with trauma-related haemorrhagic shock receiving pre-hospital care

March 25, 2022
#VisualAbstract ESCORT-HU highlights the real-life positive benefit-to-risk ratio of hydroxyurea in patients with sickle cell disease
StudyGraphics

#VisualAbstract ESCORT-HU highlights the real-life positive benefit-to-risk ratio of hydroxyurea in patients with sickle cell disease

October 8, 2021
#VisualAbstract: Immediate Transfusion in African Children with Uncomplicated Severe Anemia
StudyGraphics

#VisualAbstract: Immediate Transfusion in African Children with Uncomplicated Severe Anemia

September 4, 2019
Ticagrelor reversal agent provides immediate and sustained effect
Chronic Disease

The TRACT trial: no mortality benefit observed in African children with uncomplicated severe anemia who receive transfusion

August 2, 2019
Next Post
Parental cannabis use increasing, cigarette use decreasing

Differences in presenting emergency department symptoms for inhaled vs edible cannabis use

Half of all readmissions following lower respiratory infections occur in infants

Quick Take: Diffusion Tensor MRI of White Matter of Healthy Full-term Newborns: Relationship to Neurodevelopmental Outcomes

Parents of children with autism report greater difficulty accessing health care

Activity limitations increase risk for mental health conditions

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Abnormal menstruation may be associated with worse cardiometabolic outcomes later in life
  • Past infection with pre-omicron variants of COVID-19 protects against re-infection
  • No difference in complete expulsion of intrauterine device between early and standard interval postpartum placement
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options