Chronic Disease

1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with...

1. In this interim analysis from a randomized controlled trial, adults with biopsy-proven IgA nephropathy and persistent proteinuria who received...

1. Exposure to systemic glucocorticoid immunosuppression (gsISP) close to immune checkpoint inhibitor (ICI) initiation was associated with worse overall survival...

1. In this randomized controlled trial, tirzepatide produced substantially greater reductions in HbA1c, body weight, waist circumference, and BMI than...

1. In adult patients with chronic low back pain (LBP) and disc herniation on magnetic resonance imaging (MRI), treatment with...

1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total...

1. Physical frailty, particularly slow gait speed, was independently associated with a significantly increased risk of incident epilepsy in a...

Exercise continues to outperform pharmacologic longevity strategies Exercise remains the most consistently validated intervention for improving both lifespan and healthspan,...

1. Plasma p-tau217 was the strongest individual biomarker for predicting progression to Alzheimer's disease dementia in patients with subjective cognitive...

Metformin remains a leading candidate for pharmacologic longevity intervention Metformin continues to occupy a unique position in longevity medicine because...