Age-adjusted D-dimer levels may rule out pulmonary embolism [ADJUST-PE trial]

Image: PD  1. Baseline D-dimer levels increase with age, increasing the test false positive rate without age adjustment.  2. Age-adjusted cutoffs increase the rule-out efficacy of...

Expectant management may be appropriate in ectopic pregnancy

Image: PD  1. Approximately 40% of cases of ectopic pregnancy in hemodynamically stable women resolved on their own. 2. Among women whose β-hCG levels rose with...

Initial trial of conservative management of splenic injury [Pediatrics Classics Series]

Image: PD 1. The conservative, symptomatic management of 16 patients following assumed splenic injury from blunt abdominal trauma resulted in normalization of hemodynamic stability within...

Proton pump inhibitor boluses as effective as infusions in ulcer bleeds

1. Bleeding ulcers in the stomach and duodenum that are deemed high risk for rebleeding are defined by three endoscopically determined characteristics: active bleeding,...

Ambulances equipped for thrombolysis allow for more rapid stroke treatment

Image: PD  1. Ambulances equipped to give tissue plasminogen activator (tPA) for ischemic stroke allowed for more rapid treatment and increased rates of treatment.  2. Seven-day...

Fingolimod (Gilemya) shows promise in treatment of intracerebral hemorrhage

1. Treatment with fingolimod reduced perihematomal edema (PHE) and reduced the numbers of circulating lymphocytes in patients with intracerebral hemorrhage (ICH). 2. 100% of patients...

Ultrasound as effective as CT at identifying high-risk kidney stones, reduces radiation exposure

1. Point-of-care (POC) ultrasound was equally effective as CT scan in identifying renal calculi at “high-risk” for complications at 30-days after assessment. 2. POC...

Severity of post-concussive symptoms not predictive of recovery

1. In a prospective longitudinal study, severity of reported symptoms immediately following a concussion was not associated with delayed symptom resolution (DSR) in children. 2....

Shunt settings may have little effect on intracranial pressure in hydrocephalus

1. Shunt valve settings had less of an effect on patient intracranial pressure (ICP) than previously predicted by in vitro shunt testing.  2. Patient ICP...

Weekly dalbavancin noninferior to daily therapy for acute skin infection [DISCOVER 1 and 2...

1. Once-weekly dalbavancin was not inferior to twice-daily vancomycin and linezolid in treating acute bacterial skin infection. 2. Fewer adverse events were reported in patients...
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