Nephrology

Reports of high-impact nephrology studies by medical professionals

The 3C Study: Alemtuzumab may reduce acute rejection following kidney transplant

1. Alemtuzumab induction treatment significantly reduced events of biopsy-proven acute rejection (BPAR) when compared with standard basiliximab-based therapy (BBT).  2. Kidney graft function at six...

Low diastolic blood pressure associated with higher mortality in chronic kidney disease

Image: PD 1.  Among US veterans with non-dialysis dependent chronic kidney disease, diastolic blood pressure lower than 70 mm Hg was associated with higher mortality...

The ALTITUDE trial: Aliskiren increases the risk of adverse events and stroke without any...

Image: CC Key study points:  There was no difference in the incidence of primary outcomes (cardiovascular death, cardiac arrest with resuscitation, nonfatal MI, nonfatal stroke, etc.)...

Tolvaptan, a vasopressin receptor 2 antagonist, shows promise in polycystic kidney disease (TEMPO trial)

Image: PD/CDC. Cystic kidneys, gross pathology.  1. Tolvaptan can slow progression of autosomal dominant polycystic kidney disease both in terms of kidney volume and kidney function.  2....

Pregnancy outcomes in kidney transplant recipients encouraging

Image: PD 1. Post-kidney transplant pregnancies are mostly successful and outcomes are improving. 2. Babies of kidney transplant recipients are more likely than the general population...

[THE LANCET] Severe chronic kidney disease patients have higher coronary risk than diabetics. Time...

Image: CC/PD. Enlarged kidney (drawing).  Primer: Coronary heart disease (CHD) “equivalent”, a term used to describe some trait or factor that results in a 10-year risk...

Healthy diet delays development, progression of chronic kidney disease in diabetics

Image: PD  1. Eating a healthy diet with 5 or more servings of fruit per week led to lower risk of development or progression of...

Intravenous contrast may not increase risk of acute kidney injury

1. In a large patient cohort, the use intravenous iodinated contrast was not associated with a significantly increased risk of acute kidney injury (AKI),...

A simple, cost-effective test for monitoring lupus nephritis

Image: CC. Lupus nephritis Key findings: The spot protein:creatinine ratio, a reproducible, cost-effective, and elegant test, correlates well with the labourious 24-hour urinary total protein excretion...

ACE inhibitors associated with decreased mortality in diabetics

Image: PD  1. ACE-Inhibitors were significantly associated with decreased risk of all-cause mortality, cardiovascular death, myocardial infarction, and heart failure in patients with diabetes.  2. Angiotensin...

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