Drug improves cystic fibrosis pulmonary inflammation and protein function [PreClinical]

1. Thymosin α1 (Tα1), an immunomodulatory drug currently in use, decreased lung inflammation in a mouse model of cystic fibrosis (CF). 2. In mice, administration...

Physician reimbursement similar across Medicare Advantage and traditional Medicare plans

1. Medicare advantage and traditional Medicare physician reimbursement are relatively similar across physician services. 2. Medicare Advantage plans, however, have lower prices than traditional Medicare...

Limited evidence available to determine effectiveness and safety of cannabis to treat chronic pain

1. There is some evidence that cannabis reduces neuropathic pain, but there is inadequate evidence for other pain types. 2. Possible harms of cannabis use...

Tiotropium linked with improved outcomes in early-stage COPD

1. Patients with mild or moderate COPD (chronic obstructive pulmonary disease) randomized to receive tiotropium had a significantly higher FEV1 (forced expiratory volume in...

Coronary CT angiography linked to increased intervention, decreased myocardial infarction

1. In this meta-analysis of randomized clinical trials, coronary computed tomography angiography (CCTA) compared to functional stress testing was associated with no difference in...

Tolvaptan reduces eGFR decline in patients with polycystic kidney disease

1. Estimated glomerular filtration rate (eGFR) declined less over one year of treatment for patients with later-stage autosomal dominant polycystic kidney disease (ADPKD) taking...

Safety of MRI for patients with legacy cardiac devices

1. Patients with a legacy pacemaker or cardioverter-defibrillator were followed after undergoing medically indicated magnetic resonance imaging (MRI) examinations, and no long-term clinically significant...

Novel β-chain-targeting approach for the treatment of lymphoma [PreClinical]

1. The β-chain constant region of the T cell receptor (TCR) was targeted to specifically eliminate a population of malignant T cells. 2. Engineered chimeric...

Low prevalence of pulmonary embolism among patients with syncope

1. Based on this retrospective cohort study from multiple countries, the prevalence of pulmonary embolism among patients presenting to the emergency department (ED) with...

Vegetation size greater than 10 mm associated with increased risk of mortality in infective...

1. In this systematic review and meta-analysis, patients with infective endocardititis with vegetations greater than 10mm in size had significantly increased risk of systemic...

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