Mild hypothermia improves neurological outcome after cardiac arrest [Classics Series]
Image: PD 1. Initiation of hypothermia protocol for 24 hours after a cardiac arrest significantly improved neurological outcome in surviving...
Emergency Classics
Physician-written reports of landmark emergency medicine studies
The ARISTOTLE trial: Apixaban vs warfarin in atrial fibrillation [Classics Series]
Image: PD 1. Apixiban is superior to warfarin in preventing stroke in patients with atrial fibrillation 2. Apixaban has a...
The PLATO trial: Ticagrelor vs clopidogrel for ACS [Classics Series]
1. Treatment with ticagrelor significantly reduces mortality in patients with acute coronary syndrome when compared to clopidogrel. 2. Ticagrelor does...
The Rockall score: Risk assessment after acute upper gastrointestinal haemorrhage [Classics Series]
Image: PD 1. Age, shock, comorbidity, diagnosis, major stigmata of recent haemorrhage, and rebleeding were found to be independent predictors...
The HMPS II: Characterizing adverse events in hospitalized patients [Classics Series]
Image: PD 1. Drug-related complications were the most common type of adverse event in hospitalized patients. 2. Adverse events due to...
The CRASH-2 trial: Tranexamic acid in trauma patients [Classics Series]
Image: PD 1. Tranexamic acid significantly reduces all-cause mortality in trauma patients with significant hemorrhage. 2. There were no significant...
The COMMIT trial: Metoprolol and clopidogrel in patients with acute MI [Classics Series]
Image: PD 1. Adding early metoprolol does not further decrease the risk of death post-MI compared to conventional fibrinolytic therapy...
The LACTATE trial: Early lactate-guided therapy in intensive care patients [Classics Series]
Image: PD 1. Therapy aimed at reducing lactate levels by 20% every 2 hours during the first 8 hours of...
The EINSTEIN-PE trial: Rivaroxaban to treat pulmonary embolism [Classics Series]
Image: PD 1. Rivaroxaban, an oral factor Xa inhibitor, was non-inferior to standard anticoagulation therapy (i.e. low-molecular weight heparin and...
The EINSTEIN-DVT trial: Rivaroxaban in acute deep-vein thrombosis [Classics Series]
Image: PD 1. Rivaroxaban is non-inferior to standard therapy of enoxaparin and vitamin K antagonist in treating acute, symptomatic deep-vein...