• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

Corticosteroid use may not offer benefit for children with acute orbital cellulitis

byMolly MunsellandAlex Gipsman, MD
October 26, 2021
in Infectious Disease, Ophthalmology, Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Based on a database of 6,000 pediatric admissions for acute orbital cellulitis, corticosteroid use was not associated with decreased hospital length of stay.

2. Between 2007 and 2018, 23.8% of children admitted for orbital cellulitis received corticosteroids.

Evidence Rating Level: 2 (Good)

Study Rundown: Acute orbital cellulitis is a bacterial infection that is most common in young children, and is usually a complication of bacterial rhinosinusitis. Orbital cellulitis can lead to severe complications, including brain abscess, vision loss, meningitis, and cavernous sinus thrombosis. Hospital admission and prompt initiation of intravenous (IV) antibiotics are therefore the current standard of care. Recent small cohort studies have suggested that systemic corticosteroids may decrease orbital inflammation and reduce average hospital length of stay (LOS). This study aimed to determine whether corticosteroids were associated with decreased LOS or with other markers for complication rates in a large database. Based on nearly 6,000 admissions, 23.8% of children were prescribed corticosteroids. These children were more likely to have complicated orbital cellulitis. Rates of corticosteroid use varied widely by hospital. Overall, corticosteroid use was associated with a longer rather than shorter median LOS, although once the model was adjusted for potential confounders there was no association between corticosteroid use and LOS. This study has several limitations. Data on corticosteroid duration and dosing was not included and could potentially account for some differences in outcomes. The initial association of corticosteroid use with markers for complications suggests that corticosteroids were often used in sicker children. There is a need for prospective, controlled studies to identify specific clinical scenarios in which corticosteroid use may be appropriate. Overall, however, this large retrospective study suggests that the role for corticosteroids in the standard management of acute orbital cellulitis may be limited.

Click to read the study in Pediatrics

Relevant Reading: Management of pediatric orbital cellulitis: A systematic review

In-Depth [retrospective cohort]: This study used data from the Pediatric Health Information System (PHIS) registry and included inpatient admissions of children aged 0-17 years with a diagnosis of orbital cellulitis between 2007 and 2018. Children with underlying complex chronic diseases and other diagnoses like asthma associated with corticosteroid use were excluded. This led to the inclusion of only 49% of the orbital cellulitis encounters in the database. Among 51 hospitals included in the data, rates of corticosteroid use ranged from 1.9% to 73.7%, with 11 hospitals falling more than 3 standard deviations away from the overall mean. Generalized estimating equations models were used to identify associations with LOS. A sensitivity analysis was performed and also showed no association between LOS and corticosteroid use in patients not requiring PICU admission. Corticosteroid use was positively associated with surgery after day 2 of the admission (odds ratio 2.05) and 30-day related readmission (odds ratio 2.40) in an adjusted model.

RELATED REPORTS

Rocatinlimab may be effective in the treatment of moderate-to-severe atopic dermatitis

Wellness Check: Sleep

#VisualAbstract: Addition of itacitinib to corticosteroids did not show clinical benefit over placebo in initial treatment of acute graft-versus-host disease

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: corticosteroidsorbital cellulitisSinusitis
Previous Post

Comparing incidence and severity of COVID-19 between statin users and non-users

Next Post

#VisualAbstract: Implant-based breast reconstruction with acellular dermal matrix does not reduce reoperation rates

RelatedReports

Topical pimecrolimus use for atopic dermatitis not linked to malignancy
Chronic Disease

Rocatinlimab may be effective in the treatment of moderate-to-severe atopic dermatitis

January 31, 2023
Decline in adolescent sleep duration over past 20 years
Wellness

Wellness Check: Sleep

January 19, 2023
#VisualAbstract: Addition of itacitinib to corticosteroids did not show clinical benefit over placebo in initial treatment of acute graft-versus-host disease
StudyGraphics

#VisualAbstract: Addition of itacitinib to corticosteroids did not show clinical benefit over placebo in initial treatment of acute graft-versus-host disease

January 6, 2022
#VisualAbstract: Pericardiotomy after cardiac surgery may reduce the incidence of postoperative atrial fibrillation
StudyGraphics

#VisualAbstract: The use of COVID-19 convalescent plasma not beneficial to patients hospitalized with COVID-19

December 23, 2021
Next Post
#VisualAbstract: Implant-based breast reconstruction with acellular dermal matrix does not reduce reoperation rates

#VisualAbstract: Implant-based breast reconstruction with acellular dermal matrix does not reduce reoperation rates

Influenza vaccine not associated with increased risk of epilepsy in children

Influenza is associated with an increased odds of Parkinson Disease diagnosis after 10 years

Medical vaccine exemptions increase after elimination of nonmedical exemptions

BNT162b2 COVID-19 vaccine may reduce hospitalizations from SARS-CoV-2 delta variant for up to six months

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Cystatin C-based equation without race or sex improves accuracy of GFR estimation
  • #VisualAbstract: Aldosterone synthase inhibition reduced systolic blood pressure in patients with treatment-resistant hypertension
  • High-dose exercise therapy is not superior to low-dose exercise therapy for knee osteoarthritis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options