Tag: corticosteroids

1. Glucocorticoid dependent severe asthmatics treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared to placebo treated patients. 2. Dupilumab treated patients experienced lower rates of severe asthma exacerbations compared to those treated with placebo. Evidence Rating Level: 1 (Excellent)      Study Rundown: Patients with...

1. Adjunct long-acting muscarinic antagonist (LAMA) use with corticosteroids was associated with reduced exacerbation risk compared with placebo in patients with uncontrolled, persistent asthma. 2. LAMA, long-acting beta-agonist (LABA), and inhaled corticosteroids (triple therapy) were not associated with lower risk of exacerbations compared to LABA and inhaled corticosteroids alone. Evidence Rating...

1. In children age 5 to 11 with mild-to-moderate persistent asthma treated with daily inhaled glucocorticoids, quintupling the dose of inhaled glucocorticoids during the initial signs of worsening asthma control did not reduce the rate of severe exacerbations. 2. There was a small but significant decrease in linear growth in...

1. Patients with septic shock in the intensive care unit (ICU) undergoing mechanical ventilation receiving hydrocortisone plus fludrocortisone had a lower 90-day all-cause mortality compared to placebo treated patients. 2. The mortality rate at ICU and hospital discharge, and day 180 were significantly lower in the hydrocortisone plus fludrocortisone group,...

1. In patients with first presentation of optic neuritis, treatment with intravenous methylprednisolone followed by oral prednisone resulted in faster visual recovery when compared to placebo, though only a small benefit persisted by 6 months. 2. The use of oral prednisone alone demonstrated no benefit in terms of visual recovery...

1. In this double blind, randomized controlled trial, intra-articular triamcinolone injections did not prevent cartilage degeneration compared to saline injection controls. 2. Triamcinolone injections did not improve patients’ pain from osteoarthritis compared to controls. Evidence Rating Level: 1 (Excellent) Study Rundown: Osteoarthritis is a leading cause of disability in the United States....

1. Single glucocorticoid injections provided symptomatic relief from chronic low back pain after one month. 2. No differences in low back pain were observed between patients and controls after 12 months. Evidence Rating Level: 1 (Excellent) Study Rundown: Chronic low back pain (LBP) is known to cause long-term disability. One subtype of...

1. In this randomized controlled study of acute lumbar radiculopathy, oral prednisone improved function at weeks 3 and 52 when compared to placebo. 2. In this randomized controlled study, there was no difference between oral prednisone and placebo in improvement of below the waist pain at weeks 3 or 52...

 1. The majority of patients using pimecrolimus cream (PIM, 52.6%) or topical corticosteroids (TCS, 50.5%) for the treatment of mild to moderate atopic dermatitis were cleared of manifestations of the disease by week 3 of use. 2. No significant differences in adverse effects and safety or changes in immunity were...

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. A Randomized, Controlled Trial of Oral Propranolol in Infantile Hemangioma Infantile hemangiomas are a common nonmalignant cutaneous tumor of early childhood that can cause significant anxiety in children and their parents. While...