• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Decreased HIV co-receptor CCR5 expression after IUD insertion

byDenise PongandLeah Hawkins Bressler, MD, MPH
May 18, 2014
in Chronic Disease, Infectious Disease, Obstetrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

Image: PD 

1. HIV co-receptor CCR5 expression was reduced in endometrial and cervical T-cells following hormonal intrauterine device (IUD) insertion. 

2. T-cell activation was decreased in the endometrium of levonorgestrel IUD users but increased in the cervix of copper IUD users. 

Evidence Rating Level: 2 (Good)

Study Rundown: This study found that IUD insertion was associated with decreased expression of HIV co-receptor CCR5 in genital tract immune cells. In- and ex- vivo studies have suggested that exposure to sex hormones may increase CCR5 expression, but there is limited literature on the influence of hormonal contraception. The present work is the first study to examine the influence of IUDs on genital tract immune cells.

Limitations of this study include small sample size and short follow-up period. Large scale cohort studies and randomized controlled trials evaluating incidence of HIV among IUD users are needed to confirm this study’s findings and support the hypothesis that IUD use may be protective against HIV.

Click to read the study in AJOG

RELATED REPORTS

Long-acting cabotegravir significantly decreases incidence of HIV compared to daily oral tenofovir

Several factors influence health programs conducted in the African American Church

Liposomal amphotericin B noninferior to standard treatment for cryptococcal meningitis

Relevant Reading: Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study

In-Depth [randomized controlled trial]: This study assessed changes in cervical and endometrial immune cells in women randomized to receive a copper IUD (Cu-IUD) (n=16) or levonorgestrel IUD (LNG-IUD) (n=15). A control group receiving no IUD (n=8) was also included. Outcomes evaluated included cell numbers; expression of the CCR5 HIV co-receptor; and expression of CD69, reflecting T-cell activation.

The number of CD14+ innate immune cells in the endometrium increased in the Cu-IUD group (p<0.001). Endometrial CD8+ T-cell expression of CCR5 decreased for both IUD groups (p<0.005). CCR5 expression was also decreased in CD4+ T-cells in the endocervix of both IUD groups (p<0.05 for LNG-IUD, p<0.01 for Cu-IUD) and the endometrium of women with a LNG-IUD (p<0.001). CD69 expression was decreased in endometrial CD8+ T-cells in women with a LNG-IUD (p<0.05). Among women with a Cu-IUD, CD69 expression was increased in cervical CD4+ and CD8+ T-cells (p<0.01, p<0.05 respectively).

More from this author: Exercise associated with decreased Cesarean risk, Fetal reduction of triplets increases duration of gestation, Interpartum HIV viral load suppression improves outcomes, Low hCG in early pregnancy associated with preeclampsia, First trimester biomarkers screen for congenital heart defects

©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT

Tags: AIDSHIVintrauterine device
Previous Post

The RENAAL Trial: Losartan in diabetic nephropathy [Classics Series]

Next Post

Post-partum Implanon offers long-term contraception for high risk women

RelatedReports

Gardasil vaccine demonstrates immunogenic response at 10-year follow-up
Chronic Disease

Long-acting cabotegravir significantly decreases incidence of HIV compared to daily oral tenofovir

May 18, 2022
Wellness

Several factors influence health programs conducted in the African American Church

May 18, 2022
Pre-exposure prophylaxis (PrEP) effective in preventing HIV infection in high-risk gay men
Chronic Disease

Liposomal amphotericin B noninferior to standard treatment for cryptococcal meningitis

March 29, 2022
Increased frailty associated with childhood cancer survivorship
Oncology

Pembrolizumab as a promising treatment in patients with classic or endemic Kaposi’s sarcoma

March 27, 2022
Next Post
Clinic intervention reduces pregnancy risk behaviors in vulnerable youth

Post-partum Implanon offers long-term contraception for high risk women

Maternal vitamin D status does not affect offspring’s bone-mineral content

The VIDA trial: Vitamin D3 does not improve outcomes in asthma patients

High BMI linked to reduced risk of endometriosis

Decreased sleep in childhood linked to later central adiposity

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vitamin and mineral supplementation associated with minimal to no benefit in the primary preventing of cardiovascular disease and cancer – US Preventative Services Task Force
  • RSVpreF vaccine prevents symptomatic respiratory syncytial virus infection
  • Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.