• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

Excess antibiotic use for pneumonia associated with increase adverse events

byCaitlyn HuiandDeepti Shroff Karhade
September 17, 2019
in Infectious Disease, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this retrospective cohort study, excess days of antibiotic treatment were not associated with reduced adverse outcomes.

2. Patients who took prolonged doses of antibiotics beyond the shortest recommended dose in guidelines reported a greater number of adverse events.

Evidence Rating Level: 2 (Good)

Study Rundown: Pneumonia affects a large proportion of patients each year and is a common reason for inpatient antibiotic use and overuse. The authors of this retrospective cohort study examined predictors and outcomes associated with excess duration of antibiotic treatment for pneumonia at 43 hospitals within the Michigan hospital Medicine Safety Consortium. The primary outcome examined was the rate of excess antibiotic treatment which was assessed by subtracting the shortest effective duration of antibiotics for the patient from the actual prescribed duration. Excess antibiotic treatment was associated with increased antibiotic-related adverse events without decrease in death, readmission, emergency department visits, or Clostridioides difficile infection. One of the study limitations was that based on the retrospective nature of this study, not all patients were able to be contacted to determine any 30-day outcomes.

Click to read the study in Annals of Internal Medicine

Relevant Reading: Duration of Antibiotic Use Among Adults With Uncomplicated Community-Acquired Pneumonia Requiring Hospitalization in the United States

In-Depth [retrospective cohort study]: The authors conducted a retrospective cohort study from January 2017 to April 2018 assessing predictors and outcomes associated with excess duration of antibiotic treatment for pneumonia. A total of 7479 patients were eligible for inclusion, of which 6481 were included in the main analysis after inclusion and exclusion criteria were applied. Multivariable analyses were performed to determine predictors associated with rates of excess treatment duration and odds ratios (ORs) where reported to evaluate whether days of excess treatment were associated with adverse outcomes. Of the patients included, 67.8% of patients had excess antibiotic therapy. 73.2% had community acquired pneumonia and 26.8% had health care associated pneumonia. The authors observed that 67.8% of patients received antibiotics for longer than the shortest effective duration recommended by guidelines (71.8% [3410 of 4747] for CAP and 56.6% [981 of 1734] for HCAP). Excess duration of antibiotics was not associated with lower rates of adverse outcomes, which included death, emergency department visits and readmission. As well, the odds of a patient-reported adverse event were 5% (CI, 2% to 8%) greater for each day of excess antibiotic treatment.

RELATED REPORTS

#VisualAbstract: New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk

New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk

Clinical response to Gram stain-guided antibiotic therapy noninferior to that of guideline-based therapy in patients with ventilator-associated pneumonia

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: adverse eventantibioticantibiotic stewardshippneumonia
Previous Post

Quick Take: National Trends in the Provision of Human Milk at Hospital Discharge Among Very Low-Birth-Weight Infants

Next Post

Antimicrobial administration may dramatically reduce blood culture sensitivity in septic patients

RelatedReports

#VisualAbstract: New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk
StudyGraphics

#VisualAbstract: New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk

June 28, 2022
Rivaroxaban likely reduces risk of recurrent stroke in specific subgroup of patients with embolic stroke of undetermined source
Cardiology

New-onset atrial fibrillation following hospitalization for pneumonia associated with increased thromboembolic risk

May 30, 2022
Prescription of antibiotics for acute respiratory infections increasing
Infectious Disease

Clinical response to Gram stain-guided antibiotic therapy noninferior to that of guideline-based therapy in patients with ventilator-associated pneumonia

April 14, 2022
Of Background Image
Chronic Disease

Melioidosis outbreak is associated with imported aromatherapy spray

March 9, 2022
Next Post
High risk of complications, but low mortality among children with MRSA bacteremia

Antimicrobial administration may dramatically reduce blood culture sensitivity in septic patients

Quick Take: Safety and Efficacy of Ozanimod Versus Interferon Beta-1a in Relapsing Multiple Sclerosis (SUNBEAM)

Quick Take: Safety and Efficacy of Ozanimod Versus Interferon Beta-1a in Relapsing Multiple Sclerosis (SUNBEAM)

Earlier puberty associated with increased risk of depression in girls

SAGE-217 reduces depressive symptoms in patients with major depression within 2 weeks

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Fazirsiran reduces Z-AAT protein production in alpha1-antitrypsin deficiency
  • Arterial chemoembolization improves survival in non-resectable hepatocellular carcinoma [Classics Series]
  • #VisualAbstract: Anti-tau antibody Semorinemab not shown to slow clinical progression of Alzheimer’s disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.