Tag: pneumonia

1. Hospitalized COVID-19 patients receiving high-dose methylprednisolone followed by oral prednisone had improved clinical outcomes compared to patients receiving dexamethasone. Evidence Rating Level: 2 (Good) In June 2020, a preliminary report of a study was published comparing hospitalized COVID-19 patients receiving dexamethasone (DXM) 6 mg daily (for 10 days) to patients who...
1. Cure at 15 days occurred in 77% of patients in the placebo (3-day therapy) group compared to 68% of patients in the β-lactam (8-day therapy) group. 2. Incidence of adverse events was similar between both groups (14% placebo vs. 19% β-lactam).  Evidence Rating Level: 1 (Excellent) Study Rundown: Lower respiratory tract...
1. Five-day treatment of community-acquired pneumonia in children was comparable to standard, 10-day treatment. Evidence Rating Level: 2 (Good) Community-acquired pneumonia (CAP) is a common presenting illness among children. Due to the high occurrence, it is important to understand the most appropriate treatment for CAP among this age group. This study aimed...
1. Five-day treatment of community-acquired pneumonia in children was comparable to standard, 10-day treatment. Evidence Rating Level: 2 (Good) Community-acquired pneumonia (CAP) is a common presenting illness among children. Due to the high occurrence, it is important to understand the most appropriate treatment for CAP among this age group. This study...
1. Tocilizumab reduced the need for mechanical ventilation and lowered death outcomes in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). 2. Treatment with tocilizumab did not improve survival among patients. Evidence Rating Level: 1 (Excellent) Study Rundown: Cases pertaining to the coronavirus disease 2019 (Covid-19) have led to severe...
1. The most common complications associated with COVID-19 with high absolute risk were viral pneumonia, respiratory failure, acute kidney failure, and sepsis. 2. Complications highly associated with COVID-19 with low absolute risk were myocarditis, pneumothorax, and disseminated intravascular coagulation. Evidence Rating Level: 2 (Good) During the COVID-19 pandemic, greater than 50 million individuals...
1. In this noninferiority study, children who received placebo for pneumonia with tachypnea had a higher incidence of treatment failure compared to those who received amoxicillin. 2. Numerically, more relapses occurred in the amoxicillin control group, but the between-group difference was not statistically significant. Evidence Rating Level: 1 (Excellent) Study Rundown: The...
1. Among children with community-acquired pneumonia, proadrenomedullin more accurately predicted severe disease than established biomarkers such as C-reactive protein and procalcitonin. Evidence Rating Level: 2 (Good) Study Rundown: Health care encounters for community-acquired pneumonia (CAP) among children are both frequent and costly. Though clinical biomarkers like white blood cell count (WBC),...
1. Three-day amoxicillin treatment for chest-indrawing pneumonia was not significantly different from five-day amoxicillin treatment in HIV-uninfected children from Malawi. 2. Relapse for pneumonia was not significantly different between treatment groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Bacterial pneumonia is one of the leading causes of death for children under the...