• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

Fortification of breast milk with preterm formula powder vs human milk fortifier in preterm neonates

byBrian DoughertyandAlex Chan
May 19, 2021
in Obstetrics, Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

RELATED REPORTS

Ambient air pollution associated with increased risk of Kawasaki disease in children

#VisualAbstract: Canakinumab treatment did not reduce pain to clinical significance but shows anti-inflammatory effects in children and young adults with sickle cell anemia

2 Minute Medicine Rewind April 13, 2022

1. Fortification of expressed breast milk with preterm formula was found to be non-inferior to human milk fortifier with regards to short-term weight gain among preterm neonates.

Evidence Level Rating: 1 (Excellent)

Because expressed breast milk (EBM) is not sufficient to meet the high nutrient requirements of preterm neonates, many countries, especially low- and low-middle income countries, fortify it with human milk fortifiers (HMF). However, the prohibitively high cost and adverse effects of HMF limit its utility in resource-poor settings; as such, this study tested the hypothesis that fortification of EBM with preterm formula (PTF) is safer, more economical, and potentially a viable alternative. The study was conducted in Delhi, India, and neonates born at or before 34 weeks of gestation with a birth weight less than 1500 g were eligible. The primary outcome was the rate of in-hospital weight gain measured as gram per kilogram per day from the date of randomization to the day of discharge or 40 weeks postmenstrual age, whichever was earlier. 59 neonates were randomized to receive PTF fortification and 63 to receive HMF. The mean weight gain from the time of fortification until hospital discharge was 15.7±3.9 and 16.3±4.0 g/kg/d in the PTF and HMF cohorts, respectively (mean difference -0.5 g/kg/d, 95% CI -1.9 to 0.7). The lower bound of the 95% CI did not cross the prespecified noninferiority margin of 2 g/kg/d; thus, noninferiority of PTF was established. The gain in length and head circumference between the two cohorts was comparable. Additionally, the incidence of feeding intolerance among neonates in the PTF cohort was significantly lower (1.4 vs. 6.8 per 1,000 patient days, IRR 0.19, 95% CI 0.04 to 0.95). There was no difference in the rate of adverse outcomes like incident mortality or sepsis between the two cohorts. Overall, this study demonstrates that PTF is noninferior to commercial HMF with regards to short-term weight gain and growth and may be a more economical alternative.

Click to read the study in JAMA Pediatrics

Image: PD

©2021 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: neonatespediatrics
Previous Post

Internet based training intervention for teachers effective as a strategy to improve cardiorespiratory fitness of children

Next Post

Probiotic use not found to be an effective strategy for primary prevention of clostridioides difficile infection

RelatedReports

Isolated mild/moderate thrombocytopenia may not require intervention
Pediatrics

Ambient air pollution associated with increased risk of Kawasaki disease in children

May 9, 2022
#VisualAbstract: Canakinumab treatment did not reduce pain to clinical significance but shows anti-inflammatory effects in children and young adults with sickle cell anemia
StudyGraphics

#VisualAbstract: Canakinumab treatment did not reduce pain to clinical significance but shows anti-inflammatory effects in children and young adults with sickle cell anemia

May 4, 2022
Late gestation antidepressant use linked to postpartum hemorrhage
Weekly Rewinds

2 Minute Medicine Rewind April 13, 2022

April 18, 2022
Compliance-linked incentives increase infant immunizations rates in rural India
Weekly Rewinds

2 Minute Medicine Rewind April 11, 2022

April 11, 2022
Next Post
Implementation of pneumococcal vaccine programs linked to decreased antibiotic prescription

Probiotic use not found to be an effective strategy for primary prevention of clostridioides difficile infection

#VisualAbstract: Incidence of melanoma and non-melanoma skin cancers has increased in the USA over the past three decades

#VisualAbstract: Incidence of melanoma and non-melanoma skin cancers has increased in the USA over the past three decades

Drug-coated balloons are noninferior to drug-eluting stents for treatment of small vessel coronary artery disease

Treatment with Percutaneous Coronary Intervention versus Coronary Artery Bypass not associated with increased rate of memory decline in older adults

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Pelvic lymph node radiotherapy and androgen deprivation therapy augment progression-free status following prostatectomy
  • Operating the day after performing surgery the previous night not associated with adverse patient outcomes
  • Gratitude-focused writing may improve mental wellness during periods of chronic stress
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.