• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Hematopoietic stem cell transplantation reduces transcranial doppler velocities in children with sickle cell anemia

byQasim HussainiandDaniel Fisher
January 23, 2019
in Chronic Disease, Neurology, Oncology, Pediatrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this nonrandomized controlled intervention study, matched sibling donor stem cell transplantation (MSD-HSCT) was associated with lower transcranial doppler velocities (TCDs) at 1 year compared to chronic transfusions.

2. MSD-HSCT was also associated with changes in highest TCDs at 3 years, normalization rate at 1 year, and ferritin levels at 1 and 3 years.

Evidence Rating Level: 1 (Excellent)           

Study Rundown: Increased transcranial doppler velocity (TCD) in children with sickle cell anemia (SCA) is associated with an increased risk of ischemic stroke, stenosis, and silent cerebral infarcts. Previous studies have identified the pivotal role of chronic transfusions in reducing stroke risk, while newer studies have considered other preventive approaches such as hydroxyurea or matched sibling donor stem cell transplantation (MSD-HSCT). In this randomized control trial, children with SCA who received MSD-HSCT had lower TCDs at 1 and 3 years compared to those receiving care as usual (chronic transfusions). MSD-HSCT also led to greater normalization rates at 1 year and lower ferritin levels at 1 year and 3 years.

Overall, this study shows that children with SCA that receive MSD-HSCT have significantly lower TCDs at 1 year. The study is limited by its use of a short-term endpoints (cerebral velocities at 1 year), non-randomized design, and relatively small sample size. Further research is required to assess the effects of MSD-HSCT on clinical outcomes.

Click to read the study in JAMA

Relevant Reading: Hematopoietic stem cell transplantation for sickle cell disease: Progress and challenges

RELATED REPORTS

#VisualAbstract: Canakinumab treatment did not reduce pain to clinical significance but shows anti-inflammatory effects in children and young adults with sickle cell anemia

#VisualAbstract: Individualized dosing of anti-thymocyte globulin may improves outcomes of allogeneic haematopoietic stem-cell transplantation in children

#VisualAbstract: Moderate-dose hydroxyurea does not decrease stroke incidence but may lower hospitalization rates in children with sickle cell anaemia, compared to low-dose hydroxyurea

In-Depth [prospective cohort]: The DREPAGREFFE study is a nonrandomized, controlled, open-label intervention study that was conducted at 9 sites in France. A total of 67 children were enrolled with 32 assigned to the transplantation group and 35 to the standard care group. Study visits were completed at baseline, 1 year, and at 3 years. Primary outcome consisted of time-averaged mean of maximum velocities (TAMV) without angle correction in the 8 cerebral arteries at 1 year. There was a total of 29 secondary outcomes utilized in the study that included highest TAMV at 1 and 3 years, incidence of ischemic stroke, survival without ischemic stroke, as well as several others. In the transplantation group, highest TCDs were significantly lower on average at 1 year (129.6 cm/s vs 170.4 cm/s; p < 0.001). Similarly, highest TCDs at 3 years were lower in the transplantation group (112.4 cm/s in transplantation group vs 156.7 cm/s in standard of care; p = 0.001). Normalization at 1 year was higher in the transplantation group (80.0% in transplantation group vs 48.0% in standard of care; p < 0.05). Ferritin levels were lower in the transplantation group at 1 year (905 ng/mL in transplantation group vs 2529 ng/mL in standard of care group; p < 0.05) and 3 years (382 ng/mL in transplantation group vs 2170 ng/mL in standard of care group; p < 0.05).

Image: PD

©2019 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: sickle cell anemiastem cell transplantationtranscranial doppler velocity
Previous Post

Robust survival benefit seen in lupus nephritis patients receiving renal transplant

Next Post

Health care use stable after feeding tube placement in children with neurologic impairment

RelatedReports

#VisualAbstract: Canakinumab treatment did not reduce pain to clinical significance but shows anti-inflammatory effects in children and young adults with sickle cell anemia
StudyGraphics

#VisualAbstract: Canakinumab treatment did not reduce pain to clinical significance but shows anti-inflammatory effects in children and young adults with sickle cell anemia

May 4, 2022
#VisualAbstract: Individualized dosing of anti-thymocyte globulin may improves outcomes of allogeneic haematopoietic stem-cell transplantation in children
StudyGraphics

#VisualAbstract: Individualized dosing of anti-thymocyte globulin may improves outcomes of allogeneic haematopoietic stem-cell transplantation in children

February 17, 2022
#VisualAbstract: Moderate-dose hydroxyurea does not decrease stroke incidence but may lower hospitalization rates in children with sickle cell anaemia, compared to low-dose hydroxyurea
StudyGraphics

#VisualAbstract: Moderate-dose hydroxyurea does not decrease stroke incidence but may lower hospitalization rates in children with sickle cell anaemia, compared to low-dose hydroxyurea

January 13, 2022
#VisualAbstract ESCORT-HU highlights the real-life positive benefit-to-risk ratio of hydroxyurea in patients with sickle cell disease
StudyGraphics

#VisualAbstract ESCORT-HU highlights the real-life positive benefit-to-risk ratio of hydroxyurea in patients with sickle cell disease

October 8, 2021
Next Post
Early language exposure is predictive of language skills and IQ in school-age children

Health care use stable after feeding tube placement in children with neurologic impairment

Quick Take: Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents A Voxelwise and Genome-Wide Association Study

Quick Take: Association of a Schizophrenia-Risk Nonsynonymous Variant With Putamen Volume in Adolescents A Voxelwise and Genome-Wide Association Study

Smoking during pregnancy associated with aerobic fitness of children

Quick Take: Association of Rates of Smoking During Pregnancy With Corporate Tobacco Sales Poicies

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

Get 2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • #VisualAbstract: Severe actinic keratosis and need for additional treatment are markers for an increased risk of cutaneous squamous cell carcinoma
  • Virtual yoga and meditation intervention may be associated with increased health-related quality of life
  • Wellness Check: Mental Health
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.