Tag: sickle cell anemia

1. In this nonrandomized controlled intervention study, matched sibling donor stem cell transplantation (MSD-HSCT) was associated with lower transcranial doppler velocities (TCDs) at 1 year compared to chronic transfusions. 2. MSD-HSCT was also associated with changes in highest TCDs at 3 years, normalization rate at 1 year, and ferritin levels...
1. In this nonrandomized controlled intervention study, matched sibling donor stem cell transplantation (MSD-HSCT) was associated with lower transcranial doppler velocities (TCDs) at 1 year compared to chronic transfusions. 2. MSD-HSCT was also associated with changes in highest TCDs at 3 years, normalization rate at 1 year, and ferritin levels...
1. Among sub-Saharan African children with sickle cell anemia (SCA) treated with hydroxyurea, 5.1% experienced dose-limiting toxic events, well below the protocol-specified allowable rate of 30%. 2. Compared to pretreatment rates, children treated with hydroxyurea had significantly reduced rates of vaso-occlusive pain, infection, malaria, transfusion, and death after one year. Evidence...
1. In this meta-analysis of prospective population-based studies, sickle cell trait (SCT) was not associated with any difference in risk of first ischemic stroke. 2. After adjusting for known ischemic stroke risk factors, the presence of SCT was still not linked to any different risk of ischemic stroke. Evidence Rating Level:...
1. Patients with sickle cell disease treated with high-dose crizanlizumab experienced lower annualized rates of sickle cell crisis compared to placebo treatment, regardless of their baseline use of hydroxyurea. 2. Those treated with high-dose crizanlizumab remained without a sickle cell crisis on average significantly longer into the study period than...
1. Black U.S. soldiers with sickle cell trait had a significantly increased risk of exertional rhabdomyolysis compared to those without the trait. 2. In the same cohort of black U.S. soldiers, there was no association between sickle cell trait and incidence of mortality. Evidence Rating Level: 2 (Good)        Study Rundown: Previous studies...
Ibrutinib as Initial Therapy for Patients with Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma (CLL/SLL) is a spectrum of indolent malignant blood disorders characterized by progressive immune suppression and myelosuppression. While many patients are observed instead of given active therapy given low-grade disease, CLL is incurable and...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans Sickle cell trait (SCT), inheritance of a single copy of the sickle hemoglobin mutation, affects 1 in 12...
Originally published by Harvard Health. What Is It? Sickle cell anemia is an inherited blood disorder. It causes: Chronic destruction of red blood cells Episodes of intense pain Vulnerability to infections Organ damage In some cases, early death Hemoglobin is a protein in red blood cells that carries oxygen. People with sickle cell anemia inherit a defective type of...
1. Strong recommendations based on high-quality evidence are made supporting the referral of children with abnormal transcranial Doppler velocity to stroke-prevention specialists, with additional strong recommendations for simple or exchange blood transfusion in this cohort. 2. Strong recommendations based on high-quality evidence are made for the prompt use of...