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Home All Specialties Chronic Disease

Higher omega-3 blood levels associated with larger brain volumes

bys25qthea
January 25, 2014
in Chronic Disease, Neurology, Obstetrics
Reading Time: 2 mins read
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Image: PD 

1. Higher blood levels of DHA and EPA omega-3 fatty acids were associated with larger total and hippocampal brain volumes in post-menopausal women eight years later. 

2. No association was found between omega-3 blood levels and ischemic brain lesion volume. 

Evidence Rating Level: 2 (Good)            

Study Rundown: In this study, researchers found that higher blood levels of two marine omega-3 fatty acids, DHA and EPA, were associated with both larger hippocampal and total brain volumes. Strengths include a long follow-up time (8 years) and the use of red blood cell levels of DHA and EPA for exposure ascertainment, a measure that minimizes variability in metabolism. Additional research is merited to determine associations between omega-3 supplements with functional outcomes, like dementia severity, and assess causality.

Click to read the study in Neurology

Relevant Reading: Structural brain changes in aging

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In-Depth [prospective study]: Researchers measured red blood cell levels of two marine omega-3 fatty acids–eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—in 1,111 postmenopausal women in the Women’s Health Initiative Memory Study. Primary outcomes include MRI-assessed total brain volume at a median of eight years after blood draw.

In an adjusted model, one standard deviation of DHA/EPA level was associated with a 2.1 cm3  larger total brain volume (p=0.048) and 50 mm3 larger hippocampal volume (p=0.036). Compared with the first quartile of omega-3 levels, the fourth quartile was associated with a 159 mm3 greater hippocampal volume (p=0.034). There was no association between ischemic lesion volume and omega-3 levels.

By Maren Shapiro and Leah Hawkins, MD, MPH

More from this author: IUD contraception equally safe in teenagers as in older women, Black men less likely to receive follow-up for elevated prostate cancer marker, PSA, Intake of fish fatty acids associated with lower risk of breast cancer, USPSTF recommends chemoprevention for women at high risk for breast cancer, Insurance status affects treatment of early stage breast cancer, SERMs decrease breast cancer risk even after treatment

 ©2012-2014 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. 

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