ICD-10-CM code · FY2027
I27.21 Secondary pulmonary arterial hypertension
BillableValid for claims as a specific diagnosis code
About I27.21
EvidencePulse™by 2 Minute Medicine®
Go deeper into pulmonary hypertension.
Ask about the latest evidence, the landmark trials or what guidelines recommend, with every study cited. No ads, no sponsored answers.
Coding notes for I27.21
Applicable to Other names for conditions reported with this code.
- (Associated) (drug-induced) (toxin-induced) pulmonary arterial hypertension NOS
- (Associated) (drug-induced) (toxin-induced) (secondary) group 1 pulmonary hypertension
Code also Another code may be needed as well; the order depends on the encounter.
- associated conditions if applicable, or adverse effects of drugs or toxins, such as:
- adverse effect of appetite depressants (T50.5X5)
- congenital heart disease (Q20-Q28)
- human immunodeficiency virus [HIV] disease (B20)
- polymyositis (M33.2-)
- portal hypertension (K76.6)
- rheumatoid arthritis (M05.-)
- schistosomiasis (B65.-)
- Sjögren syndrome (M35.0-)
- systemic sclerosis (M34.-)
Also applies, from I27.2 Other secondary pulmonary hypertension
Excludes1 Not coded here: never report these together with this code (use the code given instead).
- Eisenmenger's syndrome (I27.83)
Code also Another code may be needed as well; the order depends on the encounter.
- associated underlying condition
Chapter 9 notes (apply to every code in it)
Excludes2 Not part of this condition, but a patient can have both: report both codes when both apply.
- certain conditions originating in the perinatal period (P04-P96)
- certain infectious and parasitic diseases (A00-B99)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations, and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
- systemic connective tissue disorders (M30-M36)
- transient cerebral ischemic attacks and related syndromes (G45.-)
Related codes in I27.2
Latest research on pulmonary hypertension
- #VisualAbstract: Riociguat Improves Exercise Following Balloon Pulmonary Angioplasty in Patients with Pulmonary Hypertension
- Anti-VEGF therapy for retinopathy of prematurity may be associated with pulmonary hypertension risk
- Pairing cardiac magnetic resonance with electrocardiograms (ECGs) improved artificial intelligence (AI) assessments of cardiovascular diseases
- Elevated blood pressure at discharge from delivery hospitalization predicts earlier admission postpartum
- 2 Minute Medicine Rewind February 23, 2026
Landmark trials from 2MM Classics
2MM+
Read the research behind every diagnosis
2MM+ gives you every study summary in full, Classics downloads of the landmark trials, EvidencePulse and HypeCheck, and ad-free reading.
See 2MM+ plansICD-10-CM FY2027 code set, as published by the CDC National Center for Health Statistics (NCHS) and CMS, effective October 1, 2026 to September 30, 2027. Codes, titles and notes are shown as published. Check payer rules and the official guidelines before billing. This page is not medical advice.
Get the app