• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

In utero exposure to maternal SARS-CoV-2 infection not associated with neurodevelopmental deficits at 6 months

byMolly MunsellandAlex Gipsman, MD
January 11, 2022
in Chronic Disease, Infectious Disease, Neurology, Obstetrics, Pediatrics, Public Health
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. In a prospective cohort study of about 250 infants, infants born to mothers with COVID-19 during pregnancy had no significant neurodevelopmental differences compared to unexposed infants at 6 months old.

2. Compared to a cohort born before the COVID-19 pandemic, infants born during the pandemic had lower survey scores in several neurodevelopmental domains.

Evidence Rating Level: 2 (Good)

Study Rundown: The impact, if any, of in utero exposure to SARS-CoV-2 on pediatric outcomes such as early neurological development remains unclear. This study at a single academic center in New York City aimed to identify developmental delays in a cohort of infants whose mothers had a SARS-CoV-2 infection at any point during pregnancy via comparison to unexposed infants born both during and before the COVID-19 pandemic. 255 mothers, 114 of whom had had COVID-19 during pregnancy, completed an Ages & Stages Questionnaire (ASQ-3) about their 6 month-old infants. The pre-pandemic control group included 62 infants. Exposed and unexposed infants within the pandemic cohort did not significantly differ in overall ASQ-3 scores nor in any developmental subdomains. Disease severity and timing within pregnancy also did not significantly affect scores. However, the combined group of exposed and unexposed infants born during the pandemic scored significantly lower in the gross motor, fine motor, and personal-social subdomains than the pre-pandemic group. Overall, this study suggests no direct association between in utero COVID-19 exposure and neurodevelopmental delay, but instead points to an overall epidemiologic difference associated with the COVID-19 pandemic era. This study’s relatively small size and dependence on a survey subject to recall bias are both limitations. However, a population-wide neurodevelopmental effect related to the stresses of the pandemic is plausible and warrants further study, including examination of any relationship with factors such as birth weight and prematurity.

Click to read the study in JAMA Pediatrics

Click to read an accompanying editorial in JAMA Pediatrics

Relevant Reading: Pregnancy and COVID-19

RELATED REPORTS

Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States

Molnupiravir improves outcomes in non-hospitalized COVID-19 patients

Risk of myocarditis or pericarditis after COVID-19 mRNA vaccination is highest among younger males

In-Depth [prospective cohort]: Controls were matched by infant sex, gestational age at birth, mode of delivery, and date of birth within 2 weeks. Infants born before 37 weeks gestational age were excluded. Infants in the pandemic cohort were born between March and December 2020 and the pre-pandemic cohort between November 2017 and January 2020. Maternal COVID-19 infections were identified based on polymerase chain reaction or serology test; 39 of the 114 women were asymptomatic. 5 infants in the pandemic cohort had a COVID-19 infection themselves between birth and the 6 month assessment. Analyses of covariance were used to compare infants between groups as well as within the exposed group based on factors including infection timing and severity. Mothers with SARS-CoV-2 infection differed significantly from noninfected mothers in race, ethnicity, and educational level, reflecting the disparate demographics of the pandemic. Models adjusted for maternal demographics. Exclusion of infants with asymptomatically infected mothers, preterm birth, or neonatal intensive care unit (NICU) admission in sensitivity analyses did not lead to significant differences between exposed and unexposed groups. Out of total scores of 60 on each subdomain, gross motor scores were 5.63 points lower, fine motor 6.61 points lower, and personal-social 3.71 points lower in the pandemic compared to pre-pandemic group, all with p<0.001.

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: COVID-19neurodevelopment
Previous Post

#VisualAbstract: Acral lentiginous melanoma may be associated with higher rates of sentinel lymph node positivity compared to other melanoma subtypes

Next Post

Drug overdose an important cause of death amongst people experiencing homelessness

RelatedReports

Cardiovascular events in Kawasaki Disease not significantly elevated over controls
Chronic Disease

Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States

June 24, 2022
Masks for personal protection for SARS-CoV-2 infection
Infectious Disease

Molnupiravir improves outcomes in non-hospitalized COVID-19 patients

June 23, 2022
Atrial fibrillation-specific management increases days alive and out of hospital
Cardiology

Risk of myocarditis or pericarditis after COVID-19 mRNA vaccination is highest among younger males

June 22, 2022
SARS-CoV-2 detected on various surroundings of asymptomatic COVID-19 positive infant
Infectious Disease

AZD7442 monoclonal antibodies are efficacious in the prevention of COVID-19

June 22, 2022
Next Post
Social networks play key roles in parental vaccination decisions

Drug overdose an important cause of death amongst people experiencing homelessness

Tirzepatide is superior to insulin glargine for management of type 2 diabetes and elevated cardiovascular risk

#VisualAbstract: Arterial hyperoxia associated with mortality in critically ill children admitted to the pediatric intensive care unit

#VisualAbstract: Drug-eluting stents reduced in-stent restenosis risk for high-grade intracranial atherosclerotic stenosis lesions compared to bare-metal stents

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vitamin and mineral supplementation associated with minimal to no benefit in the primary preventing of cardiovascular disease and cancer – US Preventative Services Task Force
  • RSVpreF vaccine prevents symptomatic respiratory syncytial virus infection
  • Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.