• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Incomplete HPV vaccine schedules may confer similar levels of protection

bys25qthea
June 10, 2015
in Chronic Disease, Infectious Disease, Obstetrics
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this combined post-hoc analysis of two phase 3, double-blind randomized trials, the bivalent HPV-16/18 vaccine AS04 was effective and conferred similar levels of protection to women after 3, 2, or 1 doses.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Prevention against cervical cancer with 3 doses of HPV vaccine can be challenging, especially in resource-limited settings where the burden of cervical cancer is greatest. This study assessed the efficacy of HPV vaccine regimens comprised of fewer than 3 doses using data compiled from 2 previous studies. In these studies, women were randomized to either receive a control vaccine or 3 doses of the bivalent AS04-adjuvanted HPV-16/18 vaccine. However, some women only received 1 or 2 doses due to a variety of reasons (such as pregnancy). In this post-hoc analysis, efficacy against one-time incident HPV infections after all 3 doses was compared to efficacy after receiving only 1 or 2 doses. Vaccination with the 3, 2, and 1-dose regimens demonstrated 77.0%, 76.0%, and 85.7% efficacy, respectively. As the fewer-dose regimens demonstrated similar levels of protection, the study raises the consideration of how best to allocate limited resources to maximize herd immunity, while preserving individual protection. Such a question can be best addressed with a future study that directly assesses the one-dose efficacy of the HPV-16/18 vaccine. This study was well designed and adequately powered with data from two phase 3 randomized control trials. However, women were non-randomly assigned to the dosage groups in the final analysis and therefore may have had differing levels of risk for HPV infection.

The study was funded by US National Cancer Institute, National Institutes of Health Office of Research on Women’s Health, and Ministry of Health of Costa Rica (CVT); GlaxoSmithKline Biologicals SA (PATRICIA).

Click to read the study, published today in The Lancet Oncology

Relevant Reading: Number of Human Papillomavirus Vaccine Doses and Condyloma

In-Depth [randomized controlled trial]: This is a post-hoc analysis that assessed the efficacy of the bivalent AS04-adjuvanted HPV-16/18 vaccine regimens after 3, 2, or 1 doses, based on previously collected data from the Costa Rica Vaccine and PATRICIA trials – both of which were phase 3, double-blind, randomized controlled trials. In both trials, women were randomized to receive either a vaccine or 3 doses of the HPV-16/18 vaccine. However, some women only received 1 or 2 doses. The primary endpoint was one-time detection of first HPV-16/18 infection.

RELATED REPORTS

Human papillomavirus vaccine effective in preventing infections in the United States

Human Papillomavirus self-sampling may be a culturally-sensitive alternative for Muslim women

Wellness Check: Spirituality

Overall, 22,327 women included in the analysis received 3 doses, 1,185 received 2, and 543 received 1 dose of the HPV-16/18 vaccine. Calculated post-hoc vaccine efficacies against one-time incident HPV-16/18 infection after receiving 3, 2, or 1 dose(s) were 77.0% (95% CI 74.7-79.1), 76.0% (95% CI 62.0-85.3), and 85.7% (95% CI 70.7-93.7), respectively. For women in the two-dose group, vaccine efficacy was 75.3% (95% CI 54.2-87.5) if the second dose was administered 1 month later, and 82.6% (95% CI 42.3-96.1) if the second dose was administered 6 months later.

Image: PD/CDC

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: hpvvaccines
Previous Post

Free alternatives comparable to Mini-Mental State Examination

Next Post

Rotavirus vaccine linked with decrease in acute gastroenteritis hospitalizations

RelatedReports

Reduced doses of human papillomavirus vaccine may be effective in preventing condyloma
Public Health

Human papillomavirus vaccine effective in preventing infections in the United States

June 23, 2022
Reduced HPV vaccine doses may be adequate
Infectious Disease

Human Papillomavirus self-sampling may be a culturally-sensitive alternative for Muslim women

June 20, 2022
Wellness

Wellness Check: Spirituality

June 21, 2022
Chronic Disease

Imiquimod noninferior to surgery in management of vulvar high-grade squamous intraepithelial lesions

May 17, 2022
Next Post
Low rotavirus vaccination coverage associated with ongoing disease transmission

Rotavirus vaccine linked with decrease in acute gastroenteritis hospitalizations

Traumatic spinal cord injury rates remain stable in the United States

Traumatic spinal cord injury rates remain stable in the United States

Bystander CPR positively associated with cardiac arrest survival

Bystander-initiated CPR associated with improved survival

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Risk of post-vitrectomy endophthalmitis may have increased during the COVID-19 pandemic
  • Bosniak classification system differentiates benign renal cysts from cystic carcinoma [Classics Series]
  • Cognitive behavioral therapy efficacious for treatment of comorbid posttraumatic headache and posttraumatic stress disorder symptoms among US veterans
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.