Tag: vaccines

1. In a large national survey, more than half of U.S. parents reported hesitancy in vaccinating their children against COVID-19. 2. Pediatric physicians were found to be the most trusted source of information about the COVID-19 vaccine. Evidence level: 2 (good) Study Rundown: Vaccines provide an effective prevention against illness caused by...

1. In a retrospective cohort study, children born to mothers vaccinated with the Tdap vaccine during pregnancy did not have increased rates of immune-related outcomes, sensory disorders, or neoplasms. 2. Rates of upper respiratory infections, gastrointestinal infections, and urgent care/inpatient health service use were reduced in children of mothers...

Section 4: Johnson & Johnson One of Top 5 COVID-19 Vaccine Finalists The Johnson & Johnson (J&J) Pharmaceutical Research and Development group has focused its COVID-19 vaccine efforts on a single-dose replication-defective human adenovirus 26 vector (Ad26.COV2.S).1,2,3 This vector deliver recombinant SARS-CoV-2 S protein genes to human cells. While no vaccines...

1. The overall probability of progression from phase 2 trials to FDA approval within 10 years was 1 in 10. 2. The average time from phase 2 to licensure was roughly four and a half years, although this period ranged from mere weeks to over a decade. Evidence Rating Level: 2...

1. Among a cohort of college-age young adults, having appropriate knowledge of the HPV vaccine was associated with increased uptake, while high uncertainty was associated with decreased uptake. Evidence Rating Level: 2 (Good) Study Rundown: Human papillomavirus (HPV) is the most common sexually transmitted infection in the U.S., and can lead...

1. In this cluster randomized controlled trial, researchers found that informing providers of which parents identified as vaccine hesitant on a standard screening survey had no impact on the length of time the children of these parents remained under-immunized. 2. Researchers also completed a per protocol analysis, studying only parents...

1. In this cluster randomized controlled trial, researchers found that informing providers of which parents identified as vaccine hesitant on a standard screening survey had no impact on the length of time the children of these parents remained under-immunized. 2. Researchers also completed a per protocol analysis, studying only parents...

1. In this national survey, both pediatricians and family physicians (FPs) were more likely to make a strong recommendation for the human papilloma virus (HPV) vaccine in older adolescents as compared to younger adolescents (ages 11 to 12 years). Pediatricians were more likely than FPs to use a presumptive...

Oral live-attenuated polio vaccines (OPV) and injected inactivated polio vaccines IPV) have helped eradicate wild polioviruses. However, there is still a need to develop new vaccines due to risk of outbreaks of vaccine-derived polioviruses. In the process of developing new vaccines, it is important to study the safety of...

1. Pregnant women who received discouraging information about vaccinations, regardless of whether or not they received encouraging information, were more likely to delay vaccination in their infants. 2. Positive, encouraging information about vaccines was not tied to an increase in the timeliness of infant vaccinations. Evidence Rating Level: 2 (Good) Study Rundown:...