Tag: vaccines

1. Maternal vaccination with tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) during pregnancy was found to be highly effective in preventing pertussis in newborns during the first year of life. The effect was strongest in the first 2 months of life. 2. Conversely, the cocooning strategy of vaccinating postpartum...
1. The American Academy of Pediatrics (AAP) acknowledges the many benefits of childhood immunization, both direct and indirect. These include herd immunity as a result of high immunization rates, direct protection of the immunized individual, prevention of death and disease epidemics, and cost savings into the billions. 2. The AAP...
1. In this cluster-randomized, open-label trial, a whole-cell cholera vaccine demonstrated moderate effectiveness of around 40% in protecting against severely dehydrating cholera. 2. The vaccine was well tolerated with no reported vaccine-related serious adverse events. Behavioral change had a small augmenting effect to the vaccine efficacy. Evidence Rating Level: 1...
1. Implementation of the rotavirus vaccine schedule was linked with decrease in all-cause gastroenteritis rates. 2. Gastroenteritis hospitalization rates declined similarly in males and females, all race/ethnicity groups, and all ages. Evidence Rating Level: 2 (Good) Study Rundown: Rotavirus is a contagious virus that is the most common cause of...
1. In this combined post-hoc analysis of two phase 3, double-blind randomized trials, the bivalent HPV-16/18 vaccine AS04 was effective and conferred similar levels of protection to women after 3, 2, or 1 doses. Evidence Rating Level: 1 (Excellent) Study Rundown: Prevention against cervical cancer with 3 doses of...
1. In this phase 3, randomized controlled trial, the candidate vaccine RTS,S/AS01 with or without a booster dose prevented a substantial number of clinical malaria cases in infants and children over a 3-4 year period, with increased vaccine efficacy and prolonged effect with the addition of a booster dose. 2....
1. When injected into mice, long, thin mesoporous silica rods (MSRs) spontaneously formed scaffolds that recruited large numbers of cells to the empty spaces within the scaffold. 2. MSRs loaded with various immunostimulants released their cargo gradually, and increased recruitment of activated immune cells and sustained greater antibody production as...
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Four Month Moxifloxacin-Based Regimens for Drug Sensitive Tuberculosis Shortening the duration of tuberculosis treatment would help in enhancing adherence, reducing side effects, and lowering the costs of treatment. Fluoroquinolones have been showing...
1. The majority of children (65%) diagnosed with new-onset epilepsy related to the administration of vaccinations were found to have an underlying genetic or structural neurological disorder which predisposed them to developing epilepsy.  2. The etiologies for underlying epilepsy disorders unmasked by vaccination included: chromosomal deletions, neuronal migration disorders, Dravet...
1. The BCG vaccine was found to be effective at protecting children exposed to tuberculosis (TB) from infection and progression to active disease.  2. Differences in the age of vaccination under 16 years did not affect the results.  Evidence Rating Level:  2 (Good)  Study Rundown: Clinical trials have been unable to consistently...