• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Infectious Disease

Tdap vaccination in pregnancy effective in preventing pertussis in infants

byMikhaela MontyandCordelia Ross
April 3, 2017
in Infectious Disease, Obstetrics, Pediatrics, Public Health
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. Maternal vaccination with tetanus toxoid, reduced diphtheria toxoid, acellular pertussis (Tdap) during pregnancy was found to be highly effective in preventing pertussis in newborns during the first year of life. The effect was strongest in the first 2 months of life.

2. Conversely, the cocooning strategy of vaccinating postpartum women was not found to be effective in preventing pertussis in newborns.

Evidence Rating Level: 2 (Good)       

Study Rundown: Rates of pertussis infection have been increasing in recent years,. In an effort to boost protection from pertussis among the most vulnerable population, infants under 1 year old, the Centers for Disease Control and Prevention Advisory Committee on Immunization Practices (ACIP) in 2015 recommended vaccination of all pregnant women with Tdap to boost maternal antibody transfer. This study explored the effectiveness of this strategy in preventing pertussis cases among children under 1 year old, while controlling for diphtheria, tentanus and acellular pertussis (DTap) vaccination of these children. Overall, maternal vaccination during pregnancy was found to be highly protective against infant pertussis. Pertussis risk among infants of vaccinated women decreased by over 90% in the first 2 months of life. Pertussis risk continued to be low throughout the first year of life and after controlling for infant vaccination with DTap. Conversely, maternal vaccination with Tdap after pregnancy (cocooning) did not significantly decrease the risk of pertussis in infants. These findings support a standard of care that incorporates maternal Tdap vaccination as a means to protect infants from infection. While providing evidence to further support this practice, generalizability of effect is limited by the regional location of the study population.

Click to read the study, published today in Pediatrics

Relevant Reading: Effectiveness of prenatal tetanus, diphtheria, and acellular pertussis vaccination on pertussis severity in infants

In-Depth [retrospective cohort study]: Participants included infants born at Kaiser Permanente Northern California from 2010 to 2015 (N=148 981). Pertussis cases were identified through testing of clinically suspicious patients. By 2015, 87.4% of pregnant women were vaccinated during pregnancy. Of the 17 cases of pertussis identified in the first 2 months of life, only 1 was of an infant whose mother was vaccinated with Tdap in pregnancy, resulting in an unadjusted incidence rate of 0.08 (95% CI 0.00-0.43). The unadjusted incidence rate for the first year of life was 0.35 (95% CI 0.21-0.55). Pertussis risk decreased by 91.4% in the first 2 months of life and by 69% during the first year of life after adjusting for infant vaccination with DTap. Tdap vaccine effectiveness (VE) for DTap naĂŻve infants was 87.9% (P=.009). Tdap VE was 81.4% (P=.004)for infants who had 1 DTap dose,, 6.4% (P=.901) for 2 doses and 65.9% (P=.041) for 3 doses. The percentage of mothers who received the Tdap vaccine postpartum declined from a peak of 31.7% in 2010 to a nadir of 1.8% in 2015. There was no statistically significant decrease in cases of pertussis among women who received postpartum vaccination compared to those not vaccinated at all.

RELATED REPORTS

Human papillomavirus (HPV) vaccination rates have increased in recent years

Human papillomavirus vaccine effective in preventing infections in the United States

Inactivated, adjuvant enterovirus 71 vaccine is safe and effective against fatal enterovirus infections in children aged 2-71 months

Image: PD

©2015 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: diptheriaDTaPpertussisprenataltdaptetanusvaccinationvaccines
Previous Post

Influenza vaccination in children decreases risk of death

Next Post

Body weight may not be the best way to assess cardiometabolic risk in some minority populations

RelatedReports

Mental health parity law associated with financial protection for children
Chronic Disease

Human papillomavirus (HPV) vaccination rates have increased in recent years

June 23, 2022
Reduced doses of human papillomavirus vaccine may be effective in preventing condyloma
Public Health

Human papillomavirus vaccine effective in preventing infections in the United States

June 23, 2022
Preterm infants responsive to PCV13 vaccine
Infectious Disease

Inactivated, adjuvant enterovirus 71 vaccine is safe and effective against fatal enterovirus infections in children aged 2-71 months

May 10, 2022
Medical vaccine exemptions increase after elimination of nonmedical exemptions
Chronic Disease

Vaccination leads to a small absolute risk for shoulder conditions

April 22, 2022
Next Post
Few older adolescents meet recommended levels of physical activity

Body weight may not be the best way to assess cardiometabolic risk in some minority populations

FDA-approved weight loss medications associated with weight loss at one year

Being overweight at any point in adulthood increases risk for death

Smoking during pregnancy associated with aerobic fitness of children

2 Minute Medicine Rewind April 3, 2017

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Risk of post-vitrectomy endophthalmitis may have increased during the COVID-19 pandemic
  • Bosniak classification system differentiates benign renal cysts from cystic carcinoma [Classics Series]
  • Cognitive behavioral therapy efficacious for treatment of comorbid posttraumatic headache and posttraumatic stress disorder symptoms among US veterans
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.