1. Compared to 2D mammography alone, integrated 2D and 3D mammography facilitated detection of more breast cancers in asymptomatic women.
2. Less false positives occurred with integrated mammography than with conventional 2D mammography alone.
Evidence Rating Level: 2 (Good)
Study Rundown: This study found that integrated 2D and 3D mammography, or 2D mammography combined with digital breast tomosynthesis with 3D images, detected more breast cancers than 2D mammography alone and was associated with a lower incidence of false positive findings. These results are timely given recent investigations characterizing the problem of breast cancer overdiagnosis associated with population-level mammography screenings. Strengths of this investigation include a large sample size (n=7,292) and within-subject comparisons of mammography method that allowed each woman to serve as her own control. Future investigations might employ a randomized controlled design to evaluate the long-term effects of integrated mammography on morbidity and mortality.
In-Depth [prospective comparative study]. This study assessed screening outcomes using integrated 2D and 3D mammography versus 2D mammography alone in a cohort of 7,292 asymptomatic Italian women at average risk for breast cancer (ages ≥48 years). Each participant received both 2D and 3D mammography. Outcomes included cancers detected, false positives, and incremental cancer detection.
Overall, integrated mammography yielded a detection rate of 8.1 per 1,000 screens (95% CI: 6.2-10.4) while 2D mammography alone provided a detection rate of 5.3 cancers per 1,000 screens (CI: 3.8-7.3, p<0.0001) such that the incremental improvement in cancer detection rate attributable to method was 2.7 cancers per 1,000 screens (CI: 1.7-4.2). False-positive findings were recorded in 2% (CI: 1.6-2.3) of patients with 2D mammography only and in 1% (CI: 0.8-1.3) of patients with integrated mammography (p<0.0001).
By Caroline Huang and Leah Hawkins
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