Home-based dynamic intermittent pneumatic compression therapy improves chronic stroke outcomes

1. In individuals with chronic stroke, intermittent pneumatic compression (IPC) therapy improved performance in some functional tests and reduced central and peripheral systolic blood pressure

2. IPC therapy also increased weekly physical activity time and reduced sedentary time

Evidence Rating Level: 1 (Excellent) 

This randomized controlled trial explored the effects of home-based intermittent pneumatic compression (IPC) therapy on functional and vascular health outcomes in individuals with chronic stroke. Stroke often leads to long-term disability, with many survivors experiencing gait impairments and vascular dysfunction. IPC, typically used to prevent deep vein thrombosis, may enhance blood flow, exercise capacity, and mobility by increasing venous return. Thirty-one participants (~4 years post-stroke, mean age: 64.3 years) were randomized to a 12-week IPC program using the GMOVE Suit or a control (CON) group following usual care. Functional outcomes included the 6-minute walk test (6MWT), timed-up-and-go (TUG), and 10m walk test. Vascular health was assessed through pulse wave analysis (PWA) and carotid-femoral pulse wave velocity (cfPWV). The IPC group showed significant gains in 6MWT distance (+12%, 188m vs. 167m in CON; p < 0.05), but no changes in TUG or other functional tests. They also had reduced peripheral systolic blood pressure (136.2 mmHg vs. 142.2 mmHg; p < 0.05) and central SBP (124.4 mmHg vs. 130.4 mmHg; p < 0.05). Weekly physical activity increased by ~37%, while sedentary time fell by ~18%. Despite these benefits, cfPWV and augmentation index (AIx) remained unchanged. Further studies should explore whether higher-intensity IPC improves vascular outcomes long-term.

Click to read the study in PLOSONE

Image: PD

©2025 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.