• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Intranasal corticosteroids no better than saline in treating pediatric sleep-disordered breathing

byVincent SoandAlex Gipsman, MD
January 23, 2023
in Chronic Disease, ENT, Pediatrics
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

 1. In a randomized controlled trial of children with sleep-disordered breathings, intranasal saline and intranasal corticosteroids were equally efficacious.

2. Both treatment groups had similar rates of parental satisfaction, parental and surgeon perception of the need for surgery, and rates of adverse events.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Sleep-disordered breathing (SDB), which includes snoring and obstructive sleep apnea (OSA) is common in children and impacts cognition, behavior, and cardiovascular health. Adenotonsillectomy (T&A) is the standard of care for managing moderate to severe OSA. Previous small-sized clinical trials suggest that intranasal corticosteroids may improve SDB when the diagnosis is supported by polysomnography (PSG) findings. However, pediatric PSG is often difficult to attain, especially in smaller pediatric centers. This randomized controlled trial evaluated the use of intranasal saline or corticosteroids in children with SDB symptoms regardless of PSG evaluation. Following 6 weeks of treatment, both groups had resolution of SDB symptoms in 40 to 44%% of participants. There were no differences in standardized SDB-related scores, parental satisfaction, perception of the need for surgery (from parents or surgeons), or rates of adverse events. One limitation is the exclusion of participants with severe SDB or body mass index (BMI) greater than the 97th percentile, which limits the generalizability. Overall, this study suggests that intranasal glucocorticoids may not be more effective than saline spray for the treatment of SDB in children. The resolution of symptoms regardless of therapy type suggests that either nasal saline provides some therapeutic benefit or that SDB resolves over time in a significant proportion of children.

Click here to read the article in JAMA Pediatrics

Relevant Reading: Diagnosis and management of childhood obstructive sleep apnea syndrome

RELATED REPORTS

Tirzepatide reduces obstructive sleep apnea symptoms and associated risks

Poor sleep and elevation of liver function biomarkers may be predictive of liver cancer

#VisualAbstract: Tirzepatide Improved Outcomes in Patients with Obstructive Sleep Apnea and Obesity

In-Depth [randomized controlled trial]: The MIST trial was a multi-center randomized double-blinded, placebo-controlled trial in Australia that included participants aged 3-12 years old who were referred to a specialist for SDB symptoms between 2018 and 2020. Participants were allocated to two groups with either one intranasal spray daily per nostril of (1) mometasone furoate (50 μg dose) or (2) saline for 6 weeks duration. 138 participants were randomized to each treatment group. The primary outcome was the proportion of participants with resolution of significant SDB symptoms. Secondary outcomes included SDB symptoms based on functional and behavioral performance and validated standardized scales ( Pediatric Sleep Questionnaire–SDB subscale (PSQ-SDB) and the OSA-11 and OSA-522 subset of the quality of life (PedsQL) scale). Other secondary measures included parental perception of their child’s need for surgery, willingness to proceed to surgery, and parent-perceived benefit from treatment measured by the Glasgow Child Benefit Inventory. Primary outcomes did not differ between treatment groups with 40% and 44% of participants without significant symptoms (compared to 0 participants in each group at baseline) in mometasone furoate and saline groups, respectively. No differences were seen regarding surgeon consensus for surgery at follow-up, parental perception of the need for surgery, parental satisfaction, or SDB symptoms measured by standardized scales. Rates of adverse events did not differ between groups and were most commonly epistaxis and nasal itch/irritation.

Image: PD

©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: AdenotonsillectomyObstructive Sleep Apneasleep medicinesleep-disordered breathing
Previous Post

Melatonin improves sleep onset in children with autism spectrum disorder

Next Post

Futibatinib for FGFR2 Mutated Intrahepatic Cholangiocarcinoma

RelatedReports

Admission may not be needed following sleep apnea surgery
Chronic Disease

Tirzepatide reduces obstructive sleep apnea symptoms and associated risks

October 10, 2024
Low free sugar diet reduces hepatic steatosis in nonalcoholic fatty liver disease in adolescent males
Chronic Disease

Poor sleep and elevation of liver function biomarkers may be predictive of liver cancer

July 6, 2024
#VisualAbstract: Tirzepatide Improved Outcomes in Patients with Obstructive Sleep Apnea and Obesity
StudyGraphics

#VisualAbstract: Tirzepatide Improved Outcomes in Patients with Obstructive Sleep Apnea and Obesity

July 5, 2024
Sleep duration, sleepiness, chronotype have variable associations with teen self-regulation
Pharma

Eli Lilly: Tirzepatide Shows Promise In Treating Obstructive Sleep Apnea In Two Phase 3 Clinical Trials

May 19, 2024
Next Post
Patient Basics: Biliary Colic

Futibatinib for FGFR2 Mutated Intrahepatic Cholangiocarcinoma

School nurses essential in design and implementation of school safety programs

Combined visual-olfactory training for COVID-19 resultant olfactory loss

Sleep duration inversely related to childhood type 2 diabetes risk makers

Time-restricted eating ineffective for weight loss

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Living in a marginalized neighbourhood is associated with worse outcomes in patients with myocardial infarction
  • SGLT2 inhibitors may delay cognitive impairment in elderly patients with heart failure
  • Nerandomilast slows decline in FVC in idiopathic pulmonary fibrosis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.