• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Obstetrics

Multiple colposcopy biopsies may improve cervical cancer precursor detection

byMonica ParksandDavid Wang
November 30, 2014
in Obstetrics, Oncology
Reading Time: 3 mins read
0
Share on FacebookShare on Twitter

1. An increased number of lesion-directed cervical biopsies during colposcopy was associated with increased sensitivity for the detection of high-grade squamous intraepithelial lesions.

2. The absolute increase of sensitivity was greatest for women with increased risk of high-grade squamous intraepithelial lesions.

Evidence Rating Level: 3 (Average)

Study Rundown: A colposcopic examination and biopsy is typically recommended for women with an abnormal cervical screening test to detect high-grade squamous intraepithelial lesions (HSILs). The current standard is a single biopsy of the most abnormal-appearing site during colposcopy examination. However, previous studies of colposcopy screening and vaccination trials have suggested that colposcopic biopsy fail to detect 30-50% of HSILs, and that multiple biopsies may help to improve sensitivity. The purpose of this study was to quantify the benefit of multiple lesion-directed biopsies during colposcopy.

The study analyzed the biopsy results of over 600 women that underwent multiple lesion-directed colposcopic examinations in a single-site between 2009 and 2012. The biopsy protocol allowed up to 4 directed biopsies for observed abnormal lesions. At the conclusion of this prospective observational study, the authors found that additional targeted biopsies significantly increased the sensitivity for detecting HSIL compared to a single biopsy alone. This effect was observed among all subgroups, regardless of prior risk factors.  The largest increase in sensitivity was observed in high risk patients, such as patients with referral cytology demonstrating significant results, positive HPV-16 status, and high-grade colposcopy impression. The results of this study support the implementation of multiple lesion-directed biopsies as the standard of care with colposcopy. However, the study is limited by the lack of a gold standard for HSIL detection, which may result in lesion misclassification.

Click to read the study in Journal Clinical Oncology

Relevant Reading: Detection of cervical cancer and its precursors by endocervical curettage in 13115 colposcopically guided biopsy exams

RELATED REPORTS

Human papillomavirus (HPV) vaccination rates have increased in recent years

Human Papillomavirus self-sampling may be a culturally-sensitive alternative for Muslim women

Religious attendance may be correlated with cancer screening utilization

In-Depth [prospective cohort]: This study prospectively analyzed the biopsy results of 690 women 18 years or older that underwent colposcopy from a single medical center in the US from 2009 to 2012. Exclusion criteria included previous surgical, chemotherapy, or radiation treatment for cervical neoplasia. Up to 4 directed biopsies were taken. Histologic endpoints of HSIL were defined based on the worst result from all biopsies taken. The authors also collected data from all patients on colposcopic impressions and HPV type 16 positivity. Sensitivity for detecting HSIL increased from 60.6% (95% CI: 54.8% to 66.6%) with a single biopsy to 85.6% (95% CI: 80.3% to 90.2%) with two biopsies and to 95.6% (95% CI: 91.3% to 99.2%) with three. This increase in sensitivity was seen across all subgroups, but was highest among women with high-grade colposcopic impression, HSIL cytology, and HPV-16 positivity. Only 4% of all HSILs in this study were detected by non-directed biopsy.

More from this author: Rituximab linked with reduced chronic immune disease following stem cell transplantation, High-dose prophylaxis for hemophilia increases costs with minimal benefit, Ambrisentan found ineffective against idiopathic pulmonary fibrosis

Image: PD

©2014 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. No article should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2 Minute Medicine, Inc.

Tags: cervical cancerscreening
Previous Post

Roux-en-Y gastric bypass may slow progression of diabetic retinopathy

Next Post

Patient Basics: Yaws

RelatedReports

Mental health parity law associated with financial protection for children
Chronic Disease

Human papillomavirus (HPV) vaccination rates have increased in recent years

June 23, 2022
Reduced HPV vaccine doses may be adequate
Infectious Disease

Human Papillomavirus self-sampling may be a culturally-sensitive alternative for Muslim women

June 20, 2022
Survivors of adult-onset cancers associated with increased incidence of cardiovascular disease
Oncology

Religious attendance may be correlated with cancer screening utilization

March 25, 2022
Cervical cancer screening practices less cost-effective than suggested guidelines
Oncology

Sintilimab plus anlotinib showed promising clinical and safety response to treat advanced cervical cancer

February 28, 2022
Next Post

Patient Basics: Yaws

Dual-energy CT may improve detection of acute small bowel ischemia

Dual-energy CT may improve detection of acute small bowel ischemia

Possible risk factors for sphenoid sinus tumor recurrence identified

Possible risk factors for sphenoid sinus tumor recurrence identified

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Relugolix combination therapy is efficacious for endometriosis-associated pain
  • Age-based products and longer interdose intervals may reduce the risk of cardiac disease following COVID-19 mRNA vaccination
  • OPTN and UNOS update policy regarding hepatocellular carcinoma [Classics Series]
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.