• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Gastroenterology

No difference in survival after laparoscopic versus open liver resection for colorectal metastases

byThomas SuandDeepti Shroff Karhade
December 3, 2020
in Gastroenterology, Oncology, Surgery
Reading Time: 2 mins read
1
Share on FacebookShare on Twitter

1. The rates of 5-year overall survival were found to differ by less than a percentage point between patients in the laparoscopic group and those in the open group.

2. Recurrence-free survival at 5 years was over 5% higher in the open group, but this difference was statistically insignificant as well.

Evidence Rating Level: 1 (Excellent)

Study Rundown: Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Roughly half of patients with CRC eventually develop liver metastases, which are increasingly responsive to curative resection thanks to advances in diagnostics, oncologic treatment, and surgical techniques. Laparoscopic liver surgery is minimally invasive and has been shown in numerous retrospective studies as well as the randomized controlled OSLO-COMET trial to improve short-term outcomes relative to open surgery, but the long-term effects of each approach were unclear. In this OSLO-COMET extension study, no differences in recurrence-free survival or overall survival were detected between patients in the laparoscopic group and patients in the open group at 5 years. Median recurrence-free survival was also similar between groups. However, given the limited sample size, the possibility of small to moderate differences in survival in either direction could not be excluded. This study was conducted at a single high-volume surgical center, which minimized case-to-case variation, but this design also limited generalizability to other, non-expert settings. Future multicenter randomized controlled trials may reveal more insight regarding noninferiority and other specific secondary endpoints.

Click here to read the study in Annals of Internal Medicine

Relevant Reading: Laparoscopic Versus Open Resection for Colorectal Liver Metastases: The OSLO-COMET Randomized Controlled Trial

In-Depth [randomized controlled trial]: Between February 2012 and February 2016, 280 patients with colorectal liver metastases were assigned using block randomization to receive either laparoscopic or open parenchyma-sparing liver resection (fewer than 3 consecutive liver segments). Patients who required formal hemihepatectomy, vessel or bile duct reconstruction, or ablation were excluded. Survival analysis was performed in January 2020, and median overall survival was 80 months (95% CI, 63 to 97 months) in the laparoscopic surgery group and 70 months (95% CI, 48 to 92 months) in the open surgery group (hazard ratio [HR], 0.93; 95% CI, 0.67 to 1.30). Overall survival rates for 1, 3, and 5 years were 94%, 71%, and 54%, respectively, in the laparoscopic group and 93%, 71%, and 55% in the open group (between-group difference at 5 years, 0.5 percentage point; 95% CI, −11.3 to 12.3 percentage points). Median recurrence-free survival was 17 months (95% CI, 10 to 23 months) in the laparoscopic group and 16 months (95% CI, 8 to 24 months) in the open group (HR, 1.09; 95% CI, 0.80 to 1.49; P = 0.57); the 5-year recurrence-free survival rate was slightly higher in the open surgery group (36% vs. 30%; 95% CI, −6.7 to 18.7 percentage points). A total of 60 patients required repeat surgery for recurrent liver metastases.

RELATED REPORTS

Pembrolizumab did not show overall survival benefit in patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer

Addition of atezolizumab to capecitabine + bevacizumab is not clinically beneficial in the treatment of refractory metastatic colorectal cancer

Higher abundance of dietary sulfur-reducing microbes was associated with increased risk of colorectal cancer

Image: PD

©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: colorectal cancerhemihepatectomymetastatic cancer
Previous Post

Sotagliflozin reduces cardiovascular risk for patients with diabetes and worsening heart failure

Next Post

Rilonacept may lower pericarditis recurrence in patients with relapsing pericarditis

RelatedReports

Oophorectomy associated with reduced cancer risk and all-cause mortality for BRCA1/2 patients
Oncology

Pembrolizumab did not show overall survival benefit in patients with microsatellite instability-high or mismatch repair-deficient metastatic colorectal cancer

April 18, 2022
Noninvasive imaging method detects and evaluates size of metastases
Chronic Disease

Addition of atezolizumab to capecitabine + bevacizumab is not clinically beneficial in the treatment of refractory metastatic colorectal cancer

February 25, 2022
Normal renal ultrasound only rules out high grade vesicoureteral reflux in infants
Gastroenterology

Higher abundance of dietary sulfur-reducing microbes was associated with increased risk of colorectal cancer

January 4, 2022
Provision of medically-tailored meals linked with lower admissions and medical spending
Wellness

Wellness Check: Nutrition

December 30, 2021
Next Post
Rilonacept may lower pericarditis recurrence in patients with relapsing pericarditis

Rilonacept may lower pericarditis recurrence in patients with relapsing pericarditis

Neuraxial anesthesia associated with decreased 30-day all-cause mortality for patients undergoing lower limb revascularization

E-interventions linked to short-term reduction in alcohol consumption in college students

Acamprosate found to be one of few effective and tolerable interventions for alcohol dependence

Please login to join discussion

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Stereotactic body radiotherapy as a state of the art treatment option in inoperable non-small cell lung cancer [Classics Series]
  • Health system-based care associated with better treatment use and high rates of tobacco abstinence at 3 months post-discharge in hospitalized smokers
  • APOEε4 genotype may increase risk of chronic traumatic encephalopathy following repetitive head impact
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.