• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Imaging and Intervention

Non-malignant extrapulmonary findings common in lung cancer screening program

byDavid WangandJames Roebker
March 31, 2017
in Imaging and Intervention, Oncology, Pulmonology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In a retrospective review of over 17 000 patients in the National Lung Screening Trial (NLST), there was a high prevalence of potentially significant extra-pulmonary findings.

2. The incidence of extrapulmonary malignancy detected in NLST was low.

Evidence Rating Level: 3 (Average)

Study Rundown: The NLST was a large randomized controlled trial that demonstrated that low dose CT lung cancer screening may significantly reduce lung cancer mortality. However, there is concern over whether the associated costs outweigh the benefits of early detection. Among these costs include incidental extrapulmonary findings that may lead to an invasive and costly workup for a benign lesion. The purpose of this study was to examine the prevalence of clinically significant extrapulmonary findings on chest CT in the NLST.

The study retrospectively reviewed the outcomes of over 17 000 patients in the NLST for extrapulmonary findings. At the conclusion of the trial, there was a high prevalence of extrapulmonary findings, with almost 1 in 5 patients having potentially significant extrapulmonary findings. However, the prevalence of extrapulmonary malignancies detected on screening was only 0.4%. The results of this study demonstrate a high prevalence of incidental findings and low rates of malignancy in lung cancer screening and highlight the importance of communication about incidental findings from the radiologist and the need for standardized reporting of incidental findings. The study is strengthened by the large sample size compared to previous reports based on studies in Europe and Canada. However, the study is limited by the retrospective design as well as by the lack of standardized reporting methods for extrapulmonary findings.

Click to read the study in JACR

Relevant Reading: Reduced lung-cancer mortality with low-dose computed tomographic screening

RELATED REPORTS

#VisualAbstract: Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer

Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer

#VisualAbstract: Lobar vs Sublobar Resection for Peripheral Stage IA NSCLC

In-Depth [retrospective cohort]: This was a retrospective analysis of 17 309 patients using prospective data from the NLST. The primary outcome was the prevalence of extrapulmonary findings, defined as the number of patients with greater than one findings outside the lung divided by the total number of patients screened. The secondary outcome was the extrapulmonary malignancy rate, determined from NLST outcomes data. The prevalence of extrapulmonary findings in specific organ systems was also calculated.

Among the 17 309 patients, extrapulmonary findings were reported in 10 166 patients (58.7%; 95% CI: 58.0-59.5%). Extrapulmonary findings were coded as potentially significant in 3,398 patients (19.6%; 95% CI: 19.0-20.2%). Cardiovascular findings were most common (15.2%), followed by hepatobiliary (6.1%), renal (4.5%), adrenal (2.4%), and thyroid (1.3%). Primary extrapulmonary cancers were diagnosed in 67 of 17,309 patients (0.39%; 95% CI: 0.3-0.5%). The ratio of malignancy to extrapulmonary CT findings was highest for the thyroid (1 in 14 findings), followed by the kidneys (1 in 37 findings).

Image: PD

©2017 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: incidental findingslung cancer
Previous Post

Extended rivaroxaban superior to aspirin in lowering risk of recurrent venous thromboembolism: The EINSTEIN CHOICE trial

Next Post

Nicotine ameliorates schizophrenia cognitive deficits in mice [PreClinical]

RelatedReports

#VisualAbstract: Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer
StudyGraphics

#VisualAbstract: Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer

March 17, 2023
Macitentan better than placebo for preventing progression of pulmonary arterial hypertension [SERAPHIN Trial]
Chronic Disease

Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer

March 14, 2023
#VisualAbstract: Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma
StudyGraphics

#VisualAbstract: Lobar vs Sublobar Resection for Peripheral Stage IA NSCLC

March 10, 2023
Lessons from real-world implementation of lung cancer screening
Chronic Disease

Risk model-based lung cancer screening is more cost effective than current practice

February 20, 2023
Next Post
Nicotine biomarker predicts rates of smoking cessation in response to varenicline or nicotine patch

Nicotine ameliorates schizophrenia cognitive deficits in mice [PreClinical]

Significant percentage of pediatricians dismiss families who refuse vaccines

Influenza vaccination in children decreases risk of death

Childhood asthma rates decreasing, except among the poor

Tdap vaccination in pregnancy effective in preventing pertussis in infants

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Similar perinatal outcomes observed amongst conception via natural and assisted reproductive means
  • Combination doxycycline and azithromycin therapy effective in treating severe scrub typhus
  • Adenoma detection rate is inversely associated with post-colonoscopy colorectal cancer risk
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options