• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan+
  • Wellness
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Career
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan+
  • Wellness
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Career
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Obesity may be associated with better response to immune checkpoint blockade therapy

byYidi WangandAvneesh Bhangu
April 1, 2022
in Chronic Disease, Oncology, Wellness
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this study, patients who were obese or overweight had better survival compared to normal weight patients after receiving immune checkpoint blockade treatment for their cancer.

2. In patients with high tumor mutation burden, obesity was associated with greater response rate difference.

Evidence Rating Level: 2 (Good)

In patients with cancer, a phenomenon called the “obesity paradox” has been described, where obesity was surprisingly associated with better treatment outcomes. However, it is unclear whether this association is observed across cancer types and cancer therapy modalities. In the advent of immune checkpoint blockade therapy, whether and to what degree this association is present in this context is not well understood.

This prospective cohort study included 1840 adult cancer patients (57.55% male) at Memorial Sloan Kettering Cancer Center who had received at least 1 dose of immune checkpoint blockade (ICB) treatment from 2014 through 2019. The body mass index (BMI) of patients were measured within 30 days before treatment. The primary outcomes measured were overall and progression-free survival after ICB treatment.

Compared to patients with normal weight, both obese and overweight patients had better overall survival and progression-free survival. This analysis was further stratified based on number of tumor mutations (TMB) present at time of treatment. In both patients with high (>10) and lower number of tumor mutations (<10), obesity was associated with better overall and progression-free survival. Interestingly, the response rate difference between obese and normal weight patients was larger in patients with >10 TMBs compared to those with TMB <10. This study was limited in only having BMI as a measure of obesity, which could falsely categorize someone with higher muscle mass as “obese”. Therefore, which molecular sequelae of obesity underpins this observed association remains unclear. Nonetheless, this study highlighted an association between obesity and outcomes post immunotherapy for diverse types of cancers and suggest further work to be done to better elucidate the underpinning mechanism of this observation.

RELATED REPORTS

Vegetarianism may be associated with a small increased risk of hypothyroidism

Eli Lilly Takes Legal Action Against Telehealth Startups

Ivonescimab improves survival in advanced non-small cell lung cancer

Click to read the study in JAMA Network Open 

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

 

Tags: cancerimmune checkpointnutritionobesitysurvivaltumour
Previous Post

Non-Hispanic Black patients with cancer associated with worse COVID-19 outcomes compared with White patients

Next Post

No difference in outcomes between 3 minimally invasive surgical procedures for treatment of lumbar spinal stenosis

RelatedReports

Thyroidectomy more effective than medication for Hashimoto disease with persisting symptoms
Chronic Disease

Vegetarianism may be associated with a small increased risk of hypothyroidism

May 16, 2025
Food environment associated with gestational diabetes
Pharma

Eli Lilly Takes Legal Action Against Telehealth Startups

May 15, 2025
Lessons from real-world implementation of lung cancer screening
Chronic Disease

Ivonescimab improves survival in advanced non-small cell lung cancer

April 30, 2025
#VisualAbstract: Dapagliflozin Reduced Death and Worsening Heart Failure in Transcatheter Aor-tic-Valve Implantation
StudyGraphics

#VisualAbstract: Reduced-Dose Apixaban was Noninferior to Full-Dose for Cancer-Associated Venous Thromboembolism

April 22, 2025
Next Post

No difference in outcomes between 3 minimally invasive surgical procedures for treatment of lumbar spinal stenosis

#VisualAbstract: Sirolimus plus prednisolone was superior to sirolimus monotherapy in treating patients with kaposiform hemangioendothelioma

#VisualAbstract: Sirolimus plus prednisolone was superior to sirolimus monotherapy in treating patients with kaposiform hemangioendothelioma

Being overweight and obese associated with increased incidence of chronic kidney disease

2 Minute Medicine Rewind April 4, 2022

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Vegetarianism may be associated with a small increased risk of hypothyroidism
  • Novartis and Sanofi Urge EU to Raise Drug Prices
  • Physical therapy vs. glucocorticoid injection in patients with meniscal tears and knee osteoarthritis
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Career
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.