• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • Write for us
  • Contact us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • AccountLog-in/out
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Chronic Disease

Oral corticosteroids and NSAIDs similarly effective in the treatment of acute gout

byCaitlyn HuiandSai Folmsbee
February 23, 2016
in Chronic Disease
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. In this randomized, control trial, oral prednisolone and indomethacin (NSAID) had similar analgesic effectiveness among patients with acute gout.

2. Participants did not report major adverse events during the study for either treatment.  

Evidence Rating Level: 1 (Excellent)

Study Rundown: Gout, characterized by acute attacks of inflammation due to monosodium urate crystals, is the most prevalent form of inflammatory arthritis in men. Currently, the most widely accepted treatments of gout include nonsteroidal anti-inflammatory drugs (NSAIDs) and/or colchicine. Recent randomized control trials, however, indicate that oral corticosteroids may also serve as effective first-line agents for treatment. This study aimed to evaluate the equivalence in safety and pain reduction between corticosteroids (prednisolone) and NSAIDs (oral indomethacin) in the management of patients with gout. Similar analgesic effectiveness was observed between both NSAID and corticosteroid treatment. While neither participant groups reported adverse major events, patients in the indomethacin group reported more minor adverse events than those in the prednisolone group. This study is strengthened due to its large sample population and per protocol (PP) data analysis. However, it may be limited in its definition of gout, which was diagnosed based on clinical criteria rather than joint aspiration, suggesting that some enrolled patients may not have had gout. Overall, the study suggests that prednisolone may serve as an effective and safe first-line treatment option for acute gout.

Click to read the study published today in the Annals of Internal Medicine

Relevant Reading: Comparison of Oral Prednisolone/Paracetamol and Oral Indomethacin/Paracetamol Combination Therapy in the Treatment of Acute Goutlike Arthritis

In-Depth [randomized controlled trial]: In this double-blind, randomized control trial, 416 patients aged 18 years or older were selected from 4 different emergency departments in Hong Kong. All participants met several criteria for gout, including rapid onset of severe pain and erythema of an affected joint. Data were analyzed using a per protocol (PP) approach (patients who completed 2 weeks of follow-up) and intention-to-treat (ITT) approach (all randomly assigned patients). With respect to pain change, the difference in number of patients with a clinically meaningful decrease in pain score was not statistically significant between groups. Specifically, for patients at rest, the mean decrease in pain score was 6.54 mm/h (95%CI 5.02-8.06 mm/h) for indomethacin and 5.05 mm/h (95%CI 3.56-6.55 mm/h) for prednisolone. Likewise, during activity the mean decrease in pain score was 11.69 mm/h (95%CI 10.10-13.28 mm/h) for indomethacin and 11.38 mm/h (95%CI 9.98-12.79 mm/h) for prednisolone.

RELATED REPORTS

Allopurinol does not reduce cardiovascular risk for patients with ischemic heart disease without gout

Gout flares associated with a transient increase in subsequent risk of cardiovascular events

Allopurinol does not increased mortality in gout and chronic kidney disease patients

Image: CC/Wiki

©2016 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: gout
Previous Post

Clinician-focused feedback effective at reducing unnecessary antibiotic prescriptions among general practitioners

Next Post

Nanoparticle delivery of aurora kinase inhibitor may improve tumor treatment [PreClinical]

RelatedReports

Cardiology

Allopurinol does not reduce cardiovascular risk for patients with ischemic heart disease without gout

October 18, 2022
Increased diabetes risk observed in gout patients
Cardiology

Gout flares associated with a transient increase in subsequent risk of cardiovascular events

August 8, 2022
Increased diabetes risk observed in gout patients
Chronic Disease

Allopurinol does not increased mortality in gout and chronic kidney disease patients

February 8, 2022
Implementation of pneumococcal vaccine programs linked to decreased antibiotic prescription
Chronic Disease

Use of sodium-glucose transport protein 2 inhibitors associated with lowered incidence of gout in patients with type 2 diabetes

November 23, 2021
Next Post
Development of a risk index for colorectal cancer screening

Nanoparticle delivery of aurora kinase inhibitor may improve tumor treatment [PreClinical]

Transcatheter aortic valve replacement provides only minor benefit to quality of life

Transcatheter aortic valve replacement in women linked to increased complications, decreased mortality

Nanoparticle delivery of aurora kinase inhibitor may improve tumor treatment [PreClinical]

Zika viral genome detected in the amniotic fluid of two fetuses with microcephaly

License Our Award-Winning Physician-Written Medical News and Visual Abstracts

2 Minute Medicine is the leading authoritative medical news licensing service, and the only with reports written by practicing doctors.

LICENSE CONTENT

2MM+ Premium Access

No ads & unlimited access to all current reports, over 9000 searchable archived reports, visual abstracts, Weekly Rewinds, and the online edition of The Classics Series™ textbook.

Subscription Options
2 Minute Medicine

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Efanesoctocog alfa is efficacious in treating severe hemophilia A
  • Mavacamten associated with improvement in submaximal exertional tolerance: A secondary analysis of the EXPLORER-HCM randomized trial
  • Sodium-glucose cotransporter 2 inhibitors may reduce incidence of obstructive airway disease
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • The Scan
  • Wellness
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

Want more physician-written
medical news?

Join over 10 million yearly readers and numerous companies. For healthcare professionals
and the public.

Subscribe for free today!

Subscription options