Tag: gout

 1. Febuxostat was non-inferior to allopurinol for primary cardiovascular endpoints including hospitalization for non-fatal myocardial infarction or biomarker-positive acute coronary syndrome, non-fatal stroke, or cardiovascular death during the treatment period. 2. Treatment with febuxostat was not associated with an increase in cardiovascular or all-cause mortality compared to allopurinol. Evidence Rating Level:...
Viral Load Dynamics and Disease Severity In Patients Infected With SARS-CoV-2 In Zhejiang Province, China, January-March 2020: Retrospective Cohort Study 1. Stool samples demonstrated significantly longer duration of positive viral load than both respiratory and serum samples. 2. Length of positive RNA detection was associated with disease duration with a peak...
1. Dual-energy computed tomography identified cardiovascular monosodium urate deposits reliably, with increased frequency of deposits found in patients with gout. Evidence Rating Level: 2 (Good) Hyperuricemia has been identified as a cardiovascular risk factor, and previous studies have demonstrated an association between gout and coronary heart disease. As such, there is...
Efficacy and Long-term Peripheral Sensory Neuropathy of 3 vs 6 Months of Oxaliplatin-Based Adjuvant Chemotherapy for Colon Cancer: The ACHIEVE Phase 3 Randomized Clinical Trial 1. A shortened course of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer was associated with decreased peripheral sensory neuropathy without compromising effectiveness. Evidence Rating Level:...
Gout is the most common inflammatory-type arthritis worldwide, resulting from the presence of intra-articular sodium urate crystals. In addition to painful gout attacks, resulting inflammation can result in joint damage and subcutaneous nodules. Crucial to lowering a patient’s risk of experiencing recurrent attacks are urate-lowering strategies, through both pharmacotherapy...
β-Blocker use in pregnancy and the risk of congenital malformations: an international cohort study Beta-blocker medications are commonly used in managing high blood pressure in pregnancy. With an increased prevalence of obesity and related comorbidities in women of reproductive age, exposure to anti-hypertensive medications in early pregnancy has also become...
1. Use of canakinumab was associated with reduced risk for gout attacks. 2. Canakinumab administration did not result in changes to serum uric acid levels. Evidence Rating Level: 1 (Excellent) Study Rundown: Gout is the most common inflammatory arthritis in adults, and its prevalence has increased substantially over the past several decades....
1. Colchicine, non-steroidal anti-inflammatory drugs (NSAIDs), and corticosteroids were associated with reducing pain in patients with acute gout. 2. Urate-lowering therapies may lower long-term risk for acute gout attacks.     Evidence Rating Level: 1 (Excellent) Study Rundown: Gout is one of the most painful forms of arthritis. It is caused by...
1. Synovial fluid analysis for monosodium urate (MSU) crystals is an appropriate diagnostic test for those suspected to have gout. 2. Multidimensional algorithms can help physicians make a preliminary diagnosis of gout, and dual-energy computed tomography (DECT) and ultrasonography may be appropriate techniques in certain cases of gout. Evidence Rating Level:...
1. In this randomized, control trial, oral prednisolone and indomethacin (NSAID) had similar analgesic effectiveness among patients with acute gout. 2. Participants did not report major adverse events during the study for either treatment.   Evidence Rating Level: 1 (Excellent) Study Rundown: Gout, characterized by acute attacks of inflammation due to monosodium...