• About
  • Masthead
  • License Content
  • Advertise
  • Submit Press Release
  • RSS/Email List
  • 2MM Podcast
  • Write for us
  • Contact Us
2 Minute Medicine
No Result
View All Result

No products in the cart.

SUBSCRIBE
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
2 Minute Medicine
  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan+
  • Classics™+
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
SUBSCRIBE
2 Minute Medicine
Subscribe
Home All Specialties Cardiology

Allopurinol does not reduce cardiovascular risk for patients with ischemic heart disease without gout

byNeel MistryandTeddy Guo
October 18, 2022
in Cardiology, Chronic Disease, Rheumatology
Reading Time: 2 mins read
0
Share on FacebookShare on Twitter

1. The composite score for non-fatal myocardial infarction, non-fatal stroke, and cardiovascular death was comparable between allopurinol (11.0%) and usual care (11.3%).

2. All-cause mortality was similar among both groups (10.1% allopurinol vs. 10.6% usual care).

Evidence Rating Level: 1 (Excellent)

Study Rundown: Allopurinol is often used for gout prophylaxis given its urate-lowering effect; however, treatment for asymptomatic hyperuricemia is not currently indicated. Studies show that allopurinol may have a positive impact on cardiovascular outcomes; however, current evidence is limited. This randomized trial aimed to assess the safety and efficacy of allopurinol on cardiovascular outcomes in patients with ischemic heart disease but with no history of gout. The primary outcome was a composite of non-fatal myocardial infarction (MI), non-fatal stroke, and cardiovascular death. According to study results, allopurinol was comparable to usual care for patients with cardiovascular disease. This study was strengthened by a large sample size with patients from over 400 primary care practices. However, the cohort largely favors male sex and White ethnicities which may limit its generalizability.

Click to read the study in The Lancet

Relevant Reading: Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout

RELATED REPORTS

AI-Powered Stethoscope Could Diagnose Heart Disease in Minutes

Merck’s Winrevair: Pulmonary arterial hypertension drug shows success ahead of schedule

Coronary CT-angiography-guided management improves outcomes in patients with stable chest pain

In-depth [randomized-controlled trial]: Between Feb 7, 2014, and Oct 2, 2017, 6134 patients were screened for eligibility across 18 regional centers in England and Scotland. Included were those ≥ 60 years or older with ischemic heart disease without gout. Altogether, 5721 patients (2853 to allopurinol and 2868 to usual care) were included in the intention-to-treat analysis. The mean age of patients was 72.0 years (standard deviation [SD] 6.8) and the majority were white (99.2%) males (75.5%). The primary endpoint composite of non-fatal MI, non-fatal stroke, and cardiovascular death was comparable between the allopurinol and usual care group (11.0% vs. 11.3%, 2.47 vs. 2.37 events per 100 patient-years, hazard ratio [HR] 1.04, 95% confidence interval [CI] 0.89-1.21, p=0.65). Moreover, all-cause mortality was similar for both groups (10.1% in allopurinol vs. 10.6% in usual care, HR 1.02, 95% CI 0.87-1.20, p=0.77). Findings from this study suggest that allopurinol does not decrease the risk of myocardial infarction, stroke, and cardiovascular demise among patients with ischemic heart disease.

Image: PD

©2022 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Tags: allopurinolcardiovascular diseasecardiovascular eventscardiovascular mortalitycardiovascular riskgoutheart diseasehyperuricemiaischemic heart diseaseuric acid
Previous Post

Sodium-glucose cotransporter-2 inhibitors for type 2 diabetes associated with reduced atrial fibrillation hospitalization events compared to commonly used comparators

Next Post

#VisualAbstract: Pembrolizumab provides survival benefit in PD-L1 positive advanced head and neck cancer

RelatedReports

Rapid growth of medical artificial intelligence technology usage identified from insurance claims analysis, yet major barriers to widespread adoption remain
AI Roundup

AI-Powered Stethoscope Could Diagnose Heart Disease in Minutes

May 7, 2025
Pulmonary MRI with ultrashort echo time is comparable to pulmonary CT
Pharma

Merck’s Winrevair: Pulmonary arterial hypertension drug shows success ahead of schedule

March 25, 2025
Physician visual assessment of coronary stenosis severity overestimates quantitative coronary angiography
Cardiology

Coronary CT-angiography-guided management improves outcomes in patients with stable chest pain

March 12, 2025
Prevalence of hypertension among adolescents varies by race and BMI
Cardiology

Patients with coronary artery disease have sustained elevation in blood pressure following exercise

February 28, 2025
Next Post
#VisualAbstract: Pembrolizumab provides survival benefit in PD-L1 positive advanced head and neck cancer

#VisualAbstract: Pembrolizumab provides survival benefit in PD-L1 positive advanced head and neck cancer

#VisualAbstract: Chemoradiotherapy with carboplatin is more effective than cetuximab in head and neck squamous cell carcinoma

#VisualAbstract: Rituximab plus lenalidomide shows comparable survival compared to chemotherapy for CD20⁺ follicular lymphoma

Patient Basics: Thyroid Cancer

Fine needle biopsy remains a reliable test for thyroid cancer diagnosis

2 Minute Medicine® is an award winning, physician-run, expert medical media company. Our content is curated, written and edited by practicing health professionals who have clinical and scientific expertise in their field of reporting. Our editorial management team is comprised of highly-trained MD physicians. Join numerous brands, companies, and hospitals who trust our licensed content.

Recent Reports

  • Weighted vests and resistance training confer similar outcomes for bone density in the elderly
  • Breast cancer survivors may have a lower risk of Alzheimer’s dementia
  • Evaluating scar outcomes in pediatric burn patients following skin grafting 
License Content
Terms of Use | Disclaimer
Cookie Policy
Privacy Statement (EU)
Disclaimer

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.

  • Specialties
    • All Specialties, All Recent Reports
    • Cardiology
    • Chronic Disease
    • Dermatology
    • Emergency
    • Endocrinology
    • Gastroenterology
    • Imaging and Intervention
    • Infectious Disease
    • Nephrology
    • Neurology
    • Obstetrics
    • Oncology
    • Ophthalmology
    • Pediatrics
    • Pharma
    • Preclinical
    • Psychiatry
    • Public Health
    • Pulmonology
    • Rheumatology
    • Surgery
  • AI Roundup
  • Pharma
  • The Scan
  • Classics™
    • 2MM+ Online Access
    • Paperback and Ebook
  • Rewinds
  • Visual
  • Podcasts
  • Partners
    • License Content
    • Submit Press Release
    • Advertise with Us
  • Account
    • Subscribe
    • Sign-in
    • My account
No Result
View All Result

© 2021 2 Minute Medicine, Inc. - Physician-written medical news.